右归饮对大鼠激素性股骨头坏死行为学的影响

Effects of Yougui Recipe (右归饮) on the behavioral changes in rat of steroid-induced avascular necrosis of the femoral head

目的:探讨补肾助阳中药右归饮对大鼠激素性股骨头坏死行为学的影响。方法:将30只雄性Wistar大鼠随机分为空白对照组、模型组、右归饮治疗组。采用内毒素和甲基强地松龙注射诱导造成激素性股骨头坏死后,右归饮治疗组给予右归饮灌胃(10ml/kg),空白对照组和模型组以等量生理盐水灌胃。6周后对其进行抓力、自主活动、悬尾、旷场实验和水迷宫实验等行为学观察。结果:与右归饮组比较,模型组大鼠抓力减小,自主活动减少,悬尾活动时间变少,在旷场实验中10min运动总距离明显减少,在水迷宫实验中逃避潜伏期时间明显较长,总的活动距离减少。结论:右归饮可改善激素性大鼠股骨头坏死的行为学变化。

Objective ：To explore the effect of Yougui Recipe, a kidney-supplementing and yang-activating formula which on the behavioral changes of rat of steroid-induced avascular necrosis of the femoral head （SANFH）. Methods ：Thirty Wistar rats were involved and were randomly divided into the blank control group （group A） ,the model group （group B） and the Yougui Recipe group （group C）. SANFH models were established by injection of colibacillus endotoxin and prednisolone intramuscularly. Group C was lavaged with Yougui Recipe （10 ml/kg） ,while group A and group B were lavaged with the same amount of saline. The behavior of catch force, independent activities, the tail suspension, field experiment and water cleans maze experiment were observed after 6 weeks. Results： Compared with Yougui Recipe, rats in model group ： catch force and independent activity decreases;the tail suspension activities was less time. In the desert field experiments,the total distance in 10 min movement reduced significantly. In the water maze experiment, incubation period of escape had a long time obviously, total distance of activities reduced. Conclusion： Yougui Recipe can relieve the ethologic change of rat model of steroid-induced avascular necrosis of the femoral head.