转筋草中化学成分研究

Chemical constituents from Pachysandra terminalis

研究转筋草Pachysandra terminalis化学成分。综合运用硅胶柱色谱、凝胶柱色谱、制备HPLC色谱等分离色谱法分离纯化转筋草中的化学成分,采用NMR和质谱等有机波谱学方法鉴定各单体化合物的结构。从转筋草中分离得到5个化合物,鉴定为2-甲基-3-亚甲基-1,2,5-戊三醇(1),4-甲基-3-亚甲基-1,2,5-戊三醇(2),4-甲基-3-亚甲基-1,2,5-戊三醇-5-O-β-D-吡喃葡萄糖苷(3),4-甲基-3-亚甲基-1,2,5-戊三醇-1-O-β-D-吡喃葡萄糖苷(4),(7S,8R,8'R)-(+)-落叶松醇-9-O-β-D-吡喃葡萄糖苷(5)。其中化合物1～4为新化合物,化合物5为首次从该植物中分离得到。

To study chemical constituents from Pachysandra terminalis. By repeated column chromatography, including silica gel, Toyopearl HW-40, and preparative HPLC, four new （1-4） and one known （5） compounds were isolated and purified. On the ba- sis of spectral data analysis, the structure of isolated compounds were elucidated as follow： 2-methyl-3-methylenepentane-1,2, 5-triol （1）, 4-methyl-3-methylenepentane-1, 2, 5-triol （2）, 4-methyl-3-methylenepentane-1,2, 5-triol-5-O-β-D-glucopyranoside （3）, 4-methyl-3-methylenep-entane-1, 2, 5-triol-l-O-β-D-glucopyranoside （4）, （ 7S,8R,8＇R ）-（ ＋ ）-lariciresinol-9-O-β-D-glucopyrano- side （5）. Compound 5 was isolated from this genus for the first time.