益气清肺汤联合标准桃金娘油治疗AECOPD的临床疗效研究

Clinical study of decoction of invigorating Qi and clearing lung combined standardized myrtol on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)

目的:探讨益气清肺汤联合标准桃金娘油治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:将98例AECOPD患者随机分为治疗组50例和对照组48例。2组患者均给予常规治疗,对照组用标准桃金娘油每次300 mg,每天口服3次。治疗组用中药益气清肺汤,1剂/d,分2次口服,联合标准桃金娘油,2周后分别测定2组患者临床症状、血气分析及肺功能等指标。结果:2组治疗后FEV1,FEV1%均升高。而治疗组较对照组明显升高(P<0.01);治疗后2组均出现PaO2,PaO2/FiO2上升,PaCO2降低(P<0.01),但是治疗组与对照组比PaO2,PaO2/FiO2明显升高,PaCO2明显降低(P<0.01);临床控制率分别是治疗组42.0%,对照组20.83%,2组比较有显著性差异(P<0.05);显效率分别是治疗组86.0%,对照组52.08%,2组比较差异有统计学意义(P<0.01)。结论:益气清肺汤联合标准桃金娘油可明显改善AECOPD患者血气、肺功能及临床症状。

Objective： To investigate the clinical effect of decoction of invigorating Qi and clearing lung combined standardized myrtol on acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Method： Ninety and eight patients with AECOPD patients were randomly divided into the treatment group and the control group, with 50 cases and 48 cases respectively. All the patients were given the conventional treatment. The control group was treated by standardized myrtol with 3 times a day, 300 mg each time taken orally. The treatment group was given decoction of invigorating Qi and clearing lung with 2 times a day, one dose per day taken orally, combined standardized myrtol （usage as above）. After Two weeks, the scores of clinical symptom, blood gas analysis and pul- monary function were observed. Result： Both FEV1 and FEV1% were raised in the two groups after treating. And the treatment group was significantly higher than control group （ P 〈 0.01 ）. PaO2 and PaO2/FiO2 rose, with PaCO2 decreased in the two groups （P 〈 0. 01 ）. PaO2 and PaO2/FiO2 were significantly improved, and PaCO2 was significantly decreased in the treatment group compared to the control group （P 〈 0. 01 ）. In the clinical curative effect comparison aspects, clinical control rates were 42. 0% in treatment group and 20. 83% in control group respectively, with significant difference between the two groups （P 〈 0. 05）. Significant efficiency is 86.0% in treatment group and 52.08% in control group respectively, with significant difference between the two groups （P 〈 O. O1 ）. Conclusion： Decoction of invigorating Qi and clearing lung combined with standardized myrtol can obviously improve clinical symptom, blood gas an analysis and pulmonary function in patients with AECOPD.