中医体质与2型糖尿病患者胰岛β细胞功能的关系

Relationship between TCM Constitution andβ-cell Function in Patients with Tvoe 2 Diabetes

目的:探讨中医体质分型与2型糖尿病患者胰岛β细胞分泌功能的关系。方法:对74例2型糖尿病患者采用中医体质量表进行体质辨识,并且检测空腹血糖、血脂、标准馒头餐后1、2、3 h血糖和胰岛素,计算胰岛β细胞功能指数、胰岛素抵抗指数。结果:2型糖尿病患者按中医体质分类,痰湿质、瘀血质、阴虚质比其他体质的患者多。阴虚质、瘀血质患者餐后2 h血糖较痰湿质、气虚质较高。痰湿质患者HOMA-IR指数较其他体质较高,而瘀血质患者HOMA-β指数较其他体质患者要低。结论:不同体质2型糖尿病患者之间的2 h血糖、血脂、胰岛β细胞功能指数、胰岛素抵抗指数存在差异。

Objective The study was to observe the relationship between the TCM constitution and beta-cell function of type 2 diabetes.Methods 74 type2 diabetes cases were assessed to distinguish their TCM constitution by the Questionnaire of TCM constitution.The fasting plasma glucose(FPG),blood lipids,the levels of the blood glucose and insulin after a standard meal load were determined,at the same time beta-cell function index(HOMA-β) and insulin resistance index(HOMA-IR) were calculated.Results In the type 2 diabetes,the phlegm dampness constitution,Yin deficiency constitution and blood stasis constitution were more than other constitution types.The levels of the 2 hour blood glucose in Yin deficiency constitution and blood stasis constitution was higher than that in phlegm dampness constitution and Qi deficiency constitution.HOMA-IR in phlegm dampness constitution was higher than that in other constitution types,HOMA-βin blood stasis constitution was lower than that in other constitution types.Conclusions the levels of the 2 hour blood glucose after a standard meal load,lipid, HOMA-p and HOMA-IR were different in different constitutions of type 2 diabetes.