急性心肌梗死后血浆中升高的microRNA-1与QT离散度的相关性研究

Correlation of elevated plasma microRNA-1 and QT dispersion in acute myocardial infarction

目的研究急性心肌梗死后血浆中升高的microRNA-1(miR-1)与QT离散度(QTd)的相关性及临床意义。方法选取急性心肌梗死(AMI)患者53例[无室性心律失常(VA)者40例、有VA者13例],健康对照人群49例,对血浆中miR-1的表达含量进行绝对定量,并测定心电图QT间期计算出QTd及校正的QTcd,再进行相关性分析。结果AMI患者血浆中miR-1的实际表达量和QTd及QTcd值均高于正常对照人群,而且有VA者的QTd及QTcd值均大于无VA者,QTd的延长与VA的发生密切相关,血浆中的miR-1表达水平与QTd呈正相关性。结论 AMI患者血浆中miR-1与QTd具有良好的正相关性,二者联合对AMI患者预警恶性心律失常的发生、近期预后评估具有重要的临床参考价值。

Aim To investigate the correlation and clinical significance of plasmic elevated microRNA-1（miR-1） and QT dispersion（QTd） in patients with acute myocardial infarction（AMI）.Methods Fifty-three patients with AMI including 40 without ventricular arrhythmia（VA） and 13 with VA and 49 healthy subjects received absolute quantification of plasmic miR-1 and QTd and QTcd of electrocardiography were calculated.Results Expression level of plasmic miR-1 and QTd and QTcd of AMI patients were significantly increased compared with those of controls.QTd and QTcd of patients with VA were significantly prolonged than those without VA,suggesting QTd elongation was closely related to the onset of VA.The expression level of plasmic miR-1 positively correlated with QTd.Conclusions The positive correlation between elevated plasma miR-1 and QTd is found in AMI patients.The combination of these two indicators has the important clinical reference value for the prediction of malignant arrhythmia and the assessment of recent prognosis.