残余肾功能对血液透析患者钙磷代谢的影响

Effect of residual renal function on calcium-phosphorus metabolism in hemodialysis patients

目的观察不同残余。肾功能状态对维持性血液透析患者钙磷代谢的影响。方法将维持性血液透析患者80例，按照残余肾小球滤过率（residual glomerular filtration rate，rGFR）分为A组[rGFR〉2ml·min-1·（1．73rn2）。331例、B组[rGFR〈2ml·min-1·（1．73m2）-1]49例。比较2组空腹血钙、血磷、钙磷乘积、甲状旁腺素（parathyroid hormone，PTH）的差异。结果与B组比较，A组血磷、钙磷乘积、PTH低，且差异有统计学意义（P〈0．05）；2组血钙浓度无统计学差异（P〉0．05）。结论残余肾功能可有效的纠正维持性血液透析患者的钙磷代谢紊乱，临床上应重视残余肾功能在调节钙磷代谢异常方面的积极作用，保护好维持性血液透析患者的残余肾功能。

Objective To study the effect of residual renal function on calcium-phosphorus me- tabolism in maintenance hemodialysis （MHD） patients. Methods Eighty MHD patients in our hospital were randomly divided into two groups according their residual glomerular filtration rate （IGFR）： group A （31 cases） with rGFR〉2 ml.min-1·（1.73 m2） -1 ,and group B （49 cases） with rGFR〈2 ml · min -1·（1.73 m2 ）-1. Serum calcium and phosphorus, product of calcium and phosphorus, and para- thyroid hormone （PTH） were compared between the two groups. Results As compared with group B, the patients in group A had lower Serum phosphorus, the product of calcium and phosphorus, and PTH in group A were significantly lower than those in group B （P〈0. 05）. There was no significant differ- ence in serum calcium between two groups （P〉0. 05）. Conclusions Residual renal function could ef- fectively relieve the calcium-phosphorus metabolism disorder. We should pay more attention to preserve residual renal function in hemodialysis patients.