糖尿病肾病患者胃肠激素测定及其临床意义

Determination of gastrointestinal hormones in patients with diabetic nephropathy and its clinical significance

目的:通过测定糖尿病肾病(DN)患者胃肠激素水平,探讨其在不同肾功能水平时与胃肠动力障碍的关系。方法:对32例DN患者进行生化、放免、血糖、胰岛素水平、糖化血红蛋白、促胃液素、胃动素、胰高血糖素检测,测定胃排空时间。结果:DNⅢ～Ⅳ期组较DNⅠ～Ⅱ期组促胃液素、胃动素、胰高血糖素显著升高(均为P<0.05),胃排空时间显著延长(P<0.01)。结论:DN患者肾功能状况与胃肠动力下降有明显相关性,检测DN患者胃肠激素水平对不同时期DN胃肠功能性病变的诊治具有一定意义。

Objective： To explore the relationship between the levels of gastrointestinal hormones in patients with diabetic nephropathy （DN） at different levels of renal function and gastrointestinal motility disorders. Methods： The levels of biochemistry, radioimmunoassay, blood glucose, insulin levels, glycated hemoglobin, gastrin, motilin, glucagon, and gastric emptying time in 32 cases of patients with DN were detected. Results： Levels of gastrin （ P 〈 0. 05 ）, motilin （ P 〈 0. 05 ）, glucagon （ P 〈 0. 05 ）, and gastric emptying time （ P 〈 0. 01 ） were significantly increased and extended in DN Ⅲ- IV stage group than DN Ⅰ - Ⅱ stage group. Conclusion： Renal function in patients with DN and decrease of gastrointestinal motility are significantly related. Testing the level of gastrointestinal hormonees in patients with DN is meaningful in diagnosis and treatment to patients with DN in different stages.