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内质网应激与肿瘤 被引量：11

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摘要 内质网应激(ERS)是内质网受到多种刺激导致细胞内Ca2+平衡紊乱或内质网中蛋白质堆积引发的反应,ERS中的未折叠蛋白反应(UPR)、内质网超负荷反应(EOR)可能与肿瘤的发生、发展、转移及预后密切相关。本文中作者主要介绍了与肿瘤相关的ERS信号转导通路及相关基因和蛋白的表达与肿瘤的相关性。
作者 金学英 汪步海
机构地区 扬州大学医学院苏北人民医院肿瘤科
出处 《东南大学学报（医学版）》 CAS 2013年第1期110-114,共5页 Journal of Southeast University(Medical Science Edition)
基金 苏北人民医院科学基金资助项目(yzucms201018)
关键词 内质网应激 未折叠蛋白反应 肿瘤 文献综述
分类号 R730.2 [医药卫生—肿瘤]
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参考文献35

  • 1PAHL H L. Signal transduction from the endoplasmic reticulum to the cell nucleus[J].Physiological Reviews,1999.683-701.
  • 2FABIO M A. Targeting endoplasmic reticulum signaling pathways in cancer[J].Acta Oncologica,2012.822-830.
  • 3FELS D R,KOUMENIS C. The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth[J].Cancer Biology and Therapy,2006.723-728.
  • 4ADRIENNE M,GORMA N,SANDRA J M. Stress management at the ER:regulators of ER stress-induced apoptosis[J].Pharmacology and Therapeutics,2012.306-316.
  • 5SHORE G C,PAPA F R,OAKES S A. Signaling cell death from the endoplasmic reticulum stress respons[J].Current Opinion in Cell Biology,2011.143-149.
  • 6MAIUOLO J,BULOTTA S,VERDERIO C. Selective activation of the transcription factor ATF6 mediatesendoplasmic reticulum proliferation triggered by a membraneprotein[J].Proceedings of the National Academy of Sciences(USA),2011.7832-7837.
  • 7EIKE L,PAHL A,PATRICK A. The ER overload response:activation of NF-Κb[J].Biochemical Sciences,1997,(22):63-67.
  • 8SHANSHAN L I,KAUFMAN R J. Stress signaling from the lumen of the endoplasmic reticulum:coordination of gene transcriptional and translational controls[J].Genes and Development,1999,(10):1211-1233.
  • 9CHANA S,HEA F F,WANG H. Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes[J].Cell Calcium(Edinburgh),2011.523-529.
  • 10BALKWILLl F,MANTOVANI A. Inflammation and cancer:back to Virchow[J].The Lancet,2001,(9255):539-545.

同被引文献116

  • 1Huan Fang,Wei Huang,Ying Ying Xu,Zong Hou Shen,Chao Qun Wu,Shou Yi Qiao,Yan Xu,Long Yu,Hui Li Chen.Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7721 cells[J].Cell Research,2006,16(1):82-92. 被引量：7
  • 2梁建芳,郑绘霞,李宁,程彩霞,肖虹,王宏坤.胃肠道间质瘤中P16基因甲基化和P16蛋白表达的临床意义[J].中华胃肠外科杂志,2007,10(4):372-375. 被引量：8
  • 3吴涛,季光,郑培永,柳涛.内质网应激与肝细胞凋亡[J].世界华人消化杂志,2007,15(23):2507-2515. 被引量：22
  • 4Fels DR, Koumenis C. The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth [ J]. Cancer Bio Ther,2006,5 ( 7 ) :723 - 728.
  • 5Fernandez PM, Tabbara SO, Jacobs LK. Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions [ J]. Breast Cancer Res Treat, 2000,59 (1) :15 -26.
  • 6Song MS,Park YK, Lee JH, et al. Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kirtase C-epsilon/ERK/AP-1 signaling cascade [J]. Cancer Res, 2001, 61(22) :8322 -8330.
  • 7Shuda hi, Kondoh N, Imazeki N. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis [J]. J Hepatol, 2003,38(5) :605 -614.
  • 8Rico-Bautista E, Zhu W, Kitada S, et al. Small molecule-induced mitochondrial disruption directs prostate cancer inhibition via UPR signaling [ J]. Oncotarget, 2013,4 ( 8 ) : 1212 - 1229.
  • 9Yang GH, Li S, Pcstka JJ. Down-regulation of the endoplasmic reticulum chaperone GRP78/BiP by vomitoxin (Deoxynivalcnol) [J]. Toxicol Appl Pharmacol, 2000,162 (3) :207 - 217.
  • 10Maiuolo J, Bulotta S, Verderio C ,et al. transcription factor ATF6 mediates proliferation triggered by a membrane Selective activation of the endoplasmic reticulum protein [ J]. Proe Natl Acad Sci USA ,2011,108 (19) :7832 - 7837.

引证文献11

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东南大学学报（医学版）
2013年 第1期

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