乙型肝炎病毒核心启动子区缺失突变的研究进展

Deletion mutations of the hepatitis B virus core promoter and disease progress:a short review

已知乙型肝炎病毒（hepatitis B virus,HBV）核心启动子（core promoter,CP）负责指导前基因组RNA（pregenomic RNA,pgRNA）和前核心/核心蛋白（precore/core protein,preC/C蛋白）mRNA转录,在HBV复制及形态形成过程中起关键作用[1]。CP区突变可影响HBV的复制及转录,并与肝病进展密切相关。目前国内外工作主要集中于研究A1762T/G1764A等点突变与e抗原表达及其血清学转换、肝病进展等的相关性,关于该区缺失突变的特点及其对HBV和宿主的影响等尚缺乏充分认识。

The deletion mutations within the core promoter（CP）of hepatitis B virus（HBV）not only affect HBV replication or transcription,but also influence the expression and function of viral proteins such as hepatitis B e antigen and X protein.Deletions within this region may contribute to the long existence of HBV in host and disease progression.