猪流行性腹泻病毒蛋白结构与功能的初探

Functions of proteins of porcine epidemic diarrhea virus

猪流行性腹泻是猪流行性腹泻病毒引起的猪肠道传染性疾病.该病毒属于尼多病毒目,冠状病毒属.虽然猪流行性腹泻(porcine epidemic diarrhea,PED)首次在欧洲发生,但是目前已经成为包括中国、韩国、日本、菲律宾以及泰国等亚洲国家猪产业中严重的传染性疾病,造成了严重的经济损失.目前猪传染性胃肠炎(transmissible gastroenteritis virus,TGEV)和猪流行性腹泻病毒(porcine epidemic diarrhea virus,PEDV)二联灭活苗及弱毒苗的应用大大降低了两种病毒病的发生率,但是我国目前PED的流行仍呈逐年上升趋势.目前对PEDV的致病机制了解较少,本综述目的旨在借助其他冠状病毒病毒蛋白结构和功能的研究成果,对PEDV编码的病毒蛋白进行初步分析,以期为深入研究PEDV提供一些新的思路.

Porcine epidemic diarrhea（PED） is caused by porcine epidemic diarrhea virus（PEDV）,which belongs to the order Nidovirales of the family Coronaviridae.Since PED was first discovered in Europe in 1987,it has become a severe infectious disease in Asian countries（including China,Korea,Japan,Philippines and Thailand） and has caused great economic losses in swine industry.Although bivalent vaccine for PEDV and transmissible gastroenteritis virus（TGEV,another porcine coronavirus） can decrease the incidence of both diseases,the incidence of PED is still increasing annually in China.Unfortunately,there have been few studies on viral proteins and pathogenesis of PEDV.This review aims to provide some functional insights on PEDV viral proteins based on the available information from coronaviruse studies.