轮状病毒感染机制及防治的研究进展

Rotavirus infections:mechanisms,prevention and treatment

轮状病毒是引起多种幼龄动物以及婴幼儿腹泻的重要病原体.轮状病毒感染常为隐性,但环境因素改变或机体免疫力下降则可引起该病的爆发与流行.此外,轮状病毒也是一种引起人畜共患病的病原体,对其进行深入研究具有重要的公共卫生学意义.轮状病毒感染机制和防治研究有重要实践价值.本文综述了轮状病毒病原学、临床表现以及药物和疫苗方面的研究进展,为轮状病毒病防治提供参考.

Rotavirus is an important gastrointestinal pathogen which can cause severe diarrhea in young animals and infants.Although rotavirus infections are usually latent,large-scale outbreak may occur if environmental factors change or the immune defense of hosts decreases.As rotavirus is a pathogen of zoonotic diseases,studies on rotavirus infections are of great importance in public health and clinical application.This article provides an overview of the progress in research on viral pathogen,clinical manifestations,as well as drug and vaccine research,with an aim to provide a reference for the prevention and treatment of rotavirus infections.