IL-28B基因多态性与丙型肝炎易感性的关系

Association between an IL-28B gene polymorphism and susceptibility to hepatitis C virus infection

目的:探讨白介素-28B(interleukin-28B,IL-28B)单核苷酸多态性位点rs8099917与中国丙型肝炎易感性的关系.方法:采用TaqMan SNP基因分型的方法检测中国天津地区263名丙型肝炎患者和244名健康人IL-28B rs8099917基因型和等位基因分布情况,并统计分析rs8099917基因型和等位基因在2组中分布的差异.结果:在263名丙型肝炎患者中,TT基因型223人(84.8%),TG基因型39人(14.8%),GG基因型1人(0.4%).T等位基因频率为92.2%.244名健康对照者中,TT基因型222人(91.0%),TG21人(8.60%),GG1人(0.40%),T等位基因频率为95.3%.丙型肝炎患者和健康人群TG/GG基因型频率差异有统计学意义(OR=1.810,95%CI:1.042-3.145;P=0.033).丙型肝炎患者G等位基因频率也高于健康人(OR=1.709,95%CI:1.010-2.893;P=0.044).结论:中国人群IL-28B rs8099917基因多态性与丙型肝炎病毒(hepatitis C virus,HCV)感染易感性相关联.G为HCV感染的风险等位基因.

AIM： To study the association between interleukin-28B （IL-28B） single nucleotide polymorphism （SNP） rs8099917 and susceptibility to hepatitis C virus （HCV） infection in Chinese patients. METHODS： The IL-28B rs8099917 locus was genotyped in 263 patients infected with HCV and 244 heaIthy controls using TaqMan SNP genotyping assay. The differences in rs8099917 genotypes and allele frequencies between the two groups were analyzed by statistics.RESULTS： Among 263 patients with chronic HCV, 223 （84.8%） had the TT genotype, 39（14.8%） had the TG genotype, and 1 （0.40%） carried GG genotype. The frequency of T allele was 0.922. Of 244 healthy controls, the numbers of people who carried TT, TG and GG genotypes were 222 （91.0%）, 21 （8.6%） and I （0.4%）, respectively. T allele frequency was 0.953. TG/GG genotype frequencies differed significantly between patients with chronic HCV and healthy controls （OR = 1.810, 95% CI： 1.042-3.145; P = 0.033）. Patients with HCV infection had a higher G allele frequency than healthy controls （OR = 1.709, 95% CI： 1.010-2.893; P = 0.044）.CONCLUSION： The IL-28B rs8099917 gene polymorphism correlates with susceptibility to HCV infection in Chinese patient. G allele is associated with a higher risk of HCV infection.