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TCF7L2基因与2型糖尿病发生相关性的研究进展 被引量：6

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摘要 转录因子7类似物2(TCF7L2)基因是Wnt信号通路的转录因子,表达于肠道、胰腺等多种组织。Wnt信号通路在胰岛β细胞的增殖及胰岛素的分泌中起重要作用,并影响小肠L细胞胰高血糖素样肽-1(GLP-1)的合成。TCF7L2基因是目前全基因组关联研究(GWAS)发现的与2型糖尿病(T2DM)关联度最高的基因之一,并在多种族研究中得以证实,其单核苷酸多态性及选择性剪接会影响胰岛β细胞功能及胰岛素抵抗。TCF7L2基因与T2DM相关性的深入研究与认识,为T2DM的干预和治疗提供了新思路。
作者 何珂 胡蕴 毛晓明
机构地区 南京医科大学附属南京医院南京市第一医院内分泌科
出处 《现代医学》 2013年第2期140-143,共4页 Modern Medical Journal
基金 江苏省自然科学基金资助项目(BK2011893)
关键词 转录因子7类似物2 2型糖尿病 单核苷酸多态性 选择性剪接 WNT信号通路 胰高血糖素样肽-1
分类号 R587.1 [医药卫生—内分泌]
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同被引文献164

  • 1邱阳,胡海地,张锦,翟秀岩,吴伟.中期因子在糖尿病大鼠坐骨神经中的表达及意义[J].中国医科大学学报,2005,34(3):199-200. 被引量：1
  • 2张琳.TCF7L2基因rsl2255372、rS7903146多态性与2型糖尿病的相关性研究[D].衡阳:南华大学,2010: 5.
  • 3中华医学会糖尿病学分会_中国2型糖尿病防治指南(2010年版)[J].中国医学前沿杂志:电子版,2011,3(6):54-109.
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现代医学
2013年 第2期

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