摘要
Diversity-oriented synthesis （DOS） has been widely applied in the generation of a large collection of highly functionalized molecules with diverse chemical skeletons. Herein, we report the diversity-oriented synthesis of a series of structurally diverse bicyclic substrates via an efficient tandem conjugate addition/aldol process followed by ring-closing metathesis （RCM）. This approach allows us to efficiently prepare a number of structurally complex molecules for the further chemical biology studies.
