血清中IL-17、IL-22测定在病毒性肝病患者诊疗中的应用

The clinical significance of serum interleukin-17 and interleukin-22 in diagnosis and treat of Hepatitis B

目的:研究IL-17、IL-22在乙型病毒性肝病患者诊疗中的临床意义。方法:选择172例乙型病毒性肝病患者,检测治疗前后血清IL-17、IL-22水平;并分析IL-17、IL-22与HA、LN、ⅣC、总胆红素、γ谷氨酰转肽酶相关性。结果:与正常对照相比,治疗前肝病患者血清中IL-17及IL-22水平升高均有显著性意义(P<0.01),且随着肝损害程度加重,其表达水平均依次增高(P<0.01)。IL-17、IL-22与HA、LN和ⅣC均呈正相关(P<0.05),IL-22与TBIL、γ-GT呈正相关(P<0.05)。与治疗前相比,治疗后各种肝病患者血清IL-17及IL-22均显著降低(P<0.05)。结论:联合检测IL-17、IL-22及HA、LN、ⅣC、TBIL、γ-GT等相关指标对HB的临床诊断、病情分析及考核疗效具有重要的参考价值。

Objective：To investigate clinical effects of IL-17 and IL-22 in serum of patients infected HBV.Methods： Levels of IL-17,IL-22 were investigated in 172 patients with viral hepatitis B before and after treatment,the correlation between IL-17,IL-22 and HA,LN,ⅣC,total bilirubin and γ-glutamyltranspetidase were also analyzed.Results： Levels of IL-17 and IL-22 were promoted significantly in various liver dieases compared with healthy control（P0.01）.Furthermore,IL-17 and IL-22 increased with the aggravation of hepatic lesion（P0.01）.And a significant positive correlation between the levels of IL-17/IL-22 and HA,LN,Ⅳ C was observed,respectively.The same results were seen between IL-22 and TBIL,γ-GT,respectively.The post-treatment levels of IL-17 and IL-22 decreased significantly compared with pre-treatment（P0.05）.Conclusion： The investigation of IL-17,IL-22 and related markers such as HA,LN,ⅣC,TBIL and γ-GT will provide important reference value in clinical diagnosis,analysis and therapy of HB.