摘要
目的:探讨抗凝血酶Ⅲ(AT-3)和狼疮抗凝物(LAC)联合检测对评价肺癌患者血液高凝状态的意义。方法:测定40例晚期肺癌患者、27例良性肺疾病患者和30例健康对照者血浆AT-3、LAC比值、纤维蛋白原(FIB)、D-二聚体(DD)以及全血CRP、PLT、MPV和PDW水平,计算AT-3、LAC和二者联合阳性率。结果:肺癌组AT-3显著低于而LAC比值显著高于正常对照组和良性肺疾病组(P<0.01)。<60岁组和男性组AT-3水平分别显著高于>60岁组和女性组(P<0.01)。AT-3与FIB和MPV,LAC与CRP均呈显著负相关(P<0.01)。AT-3和LAC联合检测阳性率显著高于单项检测阳性率(P<0.05)。结论:联合检测AT-3和LAC对肺癌患者高凝状态的监测具有重要价值。
Objective:To evaluate the significance of combination of antithrombin-3 and lupus anticoagulants complex in hypercoagulable state of patients with lung cancer.Methods: Blood samples from 40 cases of terminal lung cancer patients without chemotherapy,27 benign lung disease patients and 30 healthy controls were determined for the levels of antithrombin-3(AT-3),lupus anticoagulants complex(LAC) ratio,fibrinogen(FIB),D-dimer(DD),CRP,PLT,MPV and PDW.Positive rate of AT-3,LAC ratio and their combination were calculated.Results:Compared with benign lung disease group and control group,AT-3 level was significantly lower,but LAC ratio was notably higher in lung cancer group.In lung cancer patients under 60 years and male patients,AT-III level was higher than that in patients above 60 years and female patients.There was negative correlation between AT-3 and FIB or MPV,LAC ratio and CRP.Combined positive rate of AT-3 and LAC ratio was markedly higher than that of AT-3 or LAC ratio separately.Conclusion:There is important significance of combined determination of antithrombin-3 and lupus anticoagulants complex in hypercagulable state monitoring in patients with lung cancer.
出处
《中国卫生检验杂志》
北大核心
2013年第1期145-147,共3页
Chinese Journal of Health Laboratory Technology
关键词
肺癌
高凝状态
抗凝血酶Ⅲ
狼疮抗凝物
Lung cancer
Hypercoagulable state
Antithrombin-3
Lupus anticoagulants complex