甲状腺素水平变化在感染性休克患者中的临床意义

Relationship between serum free T3,T4 and APACHE Ⅱ scores in patients with septic shock

目的:本文研究了20例感染性休克患者甲状腺功能全套(包括T3,T4,TSH)和APACHE评分Ⅱ的关系。方法:甲功全套用放免法测定,APACHE评分用APACHEⅡ评分系统V1.0分析得出。结果:血清FT3和FT4水平与发病前比较明显下降,而TSH则无明显改变。进一步分析发现,FT3、FT4水平和APACHEⅡ评分呈负相关,即血清FT3和FT4水平越低,APACHEⅡ分值越高,预后越差。结论:感染性休克时FT3和FT4水平下降,且反映了病情严重程度。动态监测血清FT3和FT4水平对预后判断可能有预测价值。

Objective：To evaluate the correlation between serum free T3,T4 and APACHEⅡ scores in patients with septic shock in a general ICU.Methods： Serum levels of FT3,FT4 and TSH were assayed by radioimmunology in 20 cases of septic shock.APACHE Ⅱ scores were determined by the soft APACHE Ⅱ version 1.0.Results： In septic shock patients,serum FT3 and FT4 levels decreased after they were diagnosed as septic shock（P0.01）.But TSH did not changed.There was a negative correlation between FT3/ FT4 and APACHE Ⅱ scores（P0.01）.Conclusion： FT3 and FT4 decrease in septic shock cases.These changes reflect the condition of septic shock patients,which were valuable for predicting the prognosis.