前列腺癌患者血清OPG、BMP-7和PSA的变化及其临床意义

Changes and clinical significance of serum OPG,BMP-7 and PSA in patients with prostatic cancer

目的:探讨血清骨保护素(OPG),骨形态发生蛋白-7(BMP-7)和前列腺特有抗原(PSA)水平在前列腺癌(PCa)患者中的变化及其临床意义。方法:选取PCa患者65例和同期健康体检者65例,采用ELISA法测定血清OPG、BMP-7和PSA水平。结果:前列腺癌组血清OPG、BMP-7和PSA水平较正常对照组明显升高,且前列腺癌骨转移组OPG、BMP-7水平高于无骨转移组;随着Gleason分级升高,OPG、BMP-7和PSA表达量均有升高趋势。结论:血清OPG、BMP-7和PSA与PCa关系密切,参与了PCa的发生和发展,血清OPG、BMP-7可能为诊断前列腺癌骨转移的良好指标。

Objective：To explore the change and clinical significance of osteoprotegerin（OPG）,bone morphogenetic protein（BMP-7） and prostate specific antigen（PSA） in patients with prostatic cancer.Methods： Serum levels of OPG,BMP-7 and PSA were measured with ELISA in 65 cases of patients with prostatic cancer,and 65 healthy subjects as controls.Results： Serum OPG,BMP-7 and PSA were higher in prostatic cancer group than those in NC group,and serum OPG,BMP-7 in osseous metastasis group than those in group without osseous metastasis;With the Gleason classification increase,serum OPG,BMP-7 and PSA levels elevated.Conclusion： Serum OPG,BMP-7 and PSA have close relations with prostatic cancer,and participated in the origin and development of the prostatic cancer,which may be the good index for diagnosing osseous metastasis of prostate cancer.