尖锐湿疣患者人乳头瘤病毒的亚型分布比较

A comparison of the human papillomavirus subtype distribution in condyloma acuminatum patients

目的:探讨人乳头瘤病毒亚型的地区分布差异。方法:采用GP-PCR和基于序列分析的基因分型方法进行HPV的检测与分型,宜春、阳城、沈阳、广州为4个研究现场。将其划分成农村和城市、北方与南方分别进行比较。结果:农村和城市分别检出单一型感染39例、163例,复合型感染2例、5例,HPV亚型分别为3种、5种;北方与南方分别检出单一型感染100例、163例,复合型感染4例、5例,HPV亚型分别为5种、3种;农村与城市、北方与南方高危型与低危型分布有差异。结论:HPV11和HPV6两低危型为尖锐湿疣患者的优势亚型;农村地区和北方地区均以单一型感染为主。

Objective：To explore the subtype distribution differences of CA.Methods： GP-PCR and gene analysis based on sequence analysis were adopted.Four research sites were Yichun,Yangcheng,Shenyang and Guangzhou,which were divided into country and city,south and north to analyze the HPV subtype distribution difference.Results： Unitary type infection was found 39 cases in county and163 cases in city,while complex infection was found 2 cases in county and 5 cases in city,and there were 3 kinds of HPV subtypes in county and 5 kinds in city.There were 100 unitary type infection cases,4 complex infection cases,5 kinds of HPV subtypes in the north and163 unitary type infection cases,5 complex infection cases,3 kinds of HPV subtypes in the south.The distribution of high-risk subtype and low-risk subtype of HPV between city and county,north and south were different.The differences were statistically significant.Conclusion： HPV11 and HPV6 are the major types among CA patients;Unitary type infection is the majority both in the country and in the city.