腹腔镜妇科手术应用氟比洛芬酯超前镇痛的临床分析

Flurbiprofen axetil for preemptive analgesia after laparoscopic gynecological surgery

目的探讨氟比洛芬酯超前镇痛在妇科腹腔镜术中的镇痛效果及安全性。方法按入院先后顺序,60例ASA I～Ⅱ级需行腹腔镜术的妇科患者被随机分为观察组及对照组(n=30)。观察组在气管插管后静注氟比洛芬酯1 mg/kg,对照组术毕静注氟比洛芬酯1 mg/kg。术毕清醒后两组均静注芬太尼1μg/kg用于术后镇痛。分别记录术后各时点的VSA评分、麻醉时间、苏醒时间、术后镇痛药使用以及不良反应发生等情况。结果观察组术后4 h、8 h、12 h、24 h的VAS评分均低于对照组(P<0.05);两组的麻醉时间、麻醉苏醒,组间比较差异无统计学意义(P>0.05);术后24 h观察组使用哌替啶率明显少于对照组(P<0.05);不良反应发生率组间差异没有显著性(P>0.05)。结论氟比洛芬酯超前镇痛对妇科腹腔镜术的术后镇痛效果确切,无明显不良反应,有推广应用价值。

Objective To explore the efficacy and safety of flurbiprofen axetil for preemptive analgesia after laparoseopie gynecological surgery. Methods According to the order of admission, 60 ASA Ⅰ-Ⅱ patients of laparoscopic gynecological surgery were randomly divided into the observation group and control group （ n = 30）. After endotracheal intubation, the observation group were given intravenous flurbiprofen axetil 1 mg/kg; However, the control group was given 1 mg/kg of flurbiprofen axetil end of surgery. The VSA ratings were recorded at each time point of postoperative anesthesia time, recovery time, postoperative analgesic use, and adverse reactions occurred. Results The Observation group in the postoperative 4, 8, 12 h, 24h VAS scores were lower than the control group （ P 〈 O. 05 ） ; groups anesthesia time, the anesthesia, the difference between groups was not statistically significant （P 〉 0. 05 ） ; surgery 24 hours after the observation group, use of pethidine was significantly less than the control group （ P 〈 0. 05 ） ; the difference was not statistically significant （ P 〉 O. 05） in the incidence of adverse events between groups. Conclusions Flurbiprofen axetil preemptive analgesia on laparoscopic gynecological surgery has exact analgesic effect, has no significant adverse reactions, and has application value.