期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

阿片样物质的抗肿瘤作用研究进展 被引量：2

下载PDF
导出
摘要 阿片样物质(opioids)广泛用于癌痛治疗同时,近年来被证实还有抗肿瘤作用。阿片样物质对肿瘤生物学行为影响的研究,将为肿瘤的临床诊治提供新的依据和策略。本文从阿片样物质对肿瘤细胞的增殖和凋亡、凋亡通路、细胞周期、肿瘤血管生成与肿瘤的其他生物学特征的影响等方面对阿片样物质抗肿瘤作用的研究进展作一综述。
作者 王志学 李汝泓 雷燕 严相默
机构地区 承德医学院附属医院麻醉科 承德医学院附属医院手术室 清华大学第二附属医院麻醉与疼痛医学科
出处 《中国疼痛医学杂志》 CAS CSCD 北大核心 2013年第2期110-113,共4页 Chinese Journal of Pain Medicine
基金 承德市科学技术研究与发展计划项目(201121037)
关键词 阿片样物质 抗肿瘤作用 增殖 凋亡 凋亡通路 细胞周期 血管生成
分类号 R730.5 [医药卫生—肿瘤]
  • 相关文献

参考文献25

  • 1Hatzoglou A,Ouaf ic LH,Bakogeorgou E. Morphine cross-reacts with somatostatin receptor SSTR2 in the T-47D human breast cancer cell line and decreases cell growth[J].Cancer Research,1995.5632-5636.
  • 2Singhal PC,Kapasi AA,Reddy K. Morphine promotes apoptosis in Jurkat cells[J].Journal of Leukocyte Biology,1999.650-658.
  • 3Hatsukari I,Hitosugi N,Matsumoto I. Induction of early apoptosis marker by morphine in human lung and breast carcinoma cell lines[J].2003.2413-2417.
  • 4Sueoka E,Sueoka N,Kai Y. Anticancer activity of morphine and its synthetic derivative,KT-90,mediated through apoptosis and inhibition of NF-kappaB activation[J].Biochemical and Biophysical Research Communications,2005.566-570.
  • 5Tegeder I,Grosch S,Schmidtko A. G protein-independence G1 cell cycle block and apoptosis with morphine in adenocarcinoma cell:involvement of p53 phosphorylation[J].Cancer Research,2008.1846-1852.
  • 6Hatsukari I,Hitosugi N,Ohno R. Induction of apoptosis by morphine in human tumor cell lines in vitro[J].Anticancer Research,2007.857-864.
  • 7Yin DL,Ren XH,Zheng ZL. Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells:involvement of pertussis toxin-sensitive G proteins[J].Neuroscience Research,1997.121-127.
  • 8Kugawa F,Ueno A,Aoki M. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway[J].Biological and Pharmaceutical Bulletin,2000.930-935.
  • 9赵小冬,刘剑凯,洪敏.芬太尼对C6胶质瘤细胞增殖的影响[J].实用医学杂志,2003,19(7):705-706. 被引量：3
  • 10丁汉琳,张咸伟,张传汉.芬太尼影响MCF7细胞凋亡的实验研究[J].实用医学杂志,2004,20(12):1351-1353. 被引量：16

二级参考文献18

  • 1Loh HH, Tan PL, Smith AP. Role of receptor regulation in opioid tolerance mechanisms. Synapse, 1988, 2(4): 457 ~ 462.
  • 2Coscia CJ, Szucs M, Barg J, et al. A monoclonal antiidiotypie antibody to mu opioid and delta opioid receptors. Brain Res Mol Brain Res,1991, 9(4): 299-306.
  • 3Bohn LM, Belcheva MM, Coscia CJ.μ-opioid agonist inhibition of кopioid receptor-stimulated extracellular signal-regulated kinase phosphorylation is dynamin-dependent in C6 glioma cells. J Neurochem, 2000, 74(2) : 574 ~ 581.
  • 4Barg J. Belcheva MM, MaHale RJ, et al. Beta-endorphin is a potent inhibitor of thymidine incorporation into DNA via μ and opioid receptors in fetal rat brain cell aggregates in culture. J.Nenrochem, 1993, 60(2):765 ~ 767.
  • 5Page GG, Blakely WP, Ben-Eliyahu S. Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats. Pain,2001, 90(1-2): 191 ~ 199.
  • 6Tegeder I, Grosch S, Schmidtko A, et al. G protein-independence G1 cell cycle block and apoptosis with morphine in adenocarcinoma cell: involvement of p53 phosphorylation[J]. Cancer Res, 2003, 63(8): 1846-1852
  • 7Hatzoglou A, Bakogeorgou E, Castanas E. The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors[J]. Eur J Pharmacol, 1996, 296(2): 199-207
  • 8Hatzoglou A, Ouafik L, Bakogeorgou E, et al. Morphine cross-reacts with somatostatin receptor SSTR2 in the T47D human breast cancer cell line and decreases cell growth[J]. Cancer Res, 1995, 55(23): 5632-5636
  • 9Singhal PC, Sharma P, Sanwal V, et al. Morphine modulates proliferation of kidney fibroblasts[J]. Kidney Int, 1998, 53(2): 350-357
  • 10Maneckjee R, Biswas R, Vonderhaar BK. Binding of opioids to human MCF-7 breast cancer cells and their effects on growth[J]. Cancer Res, 1990, 50(8): 2234-2238

共引文献20

同被引文献41

引证文献2

二级引证文献13

中国疼痛医学杂志
2013年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部