丹参川芎嗪、曲美他嗪、前列地尔联合治疗不稳定型心绞痛的临床疗效分析

The analysis of the effect of the joint method containing salvia tetramethylpyrazine, trimetazidine, alprostadil in the treatment of unstable angina

目的评价丹参川芎嗪、曲美他嗪、前列地尔联合治疗不稳定型心绞痛的可行性。方法将70例符合入组标准的不稳定型心绞痛患者随机分为观察组35例和对照组35例，对照组口服曲美他嗪20mg，3次／d；静脉滴注前列地尔100mg。1次／d，观察组在对照组基础上静脉滴注丹参川芎嗪注射液10ml。1次／d，两组均治疗14d，观察治疗前后心绞痛发作频率与持续时间，进行心电图监测，比较两组临床疗效差异。结果观察组总有效率100％，显效率86％；对照组总有效率91％，显效率60％。观察组总有效率、显效率均显著高于对照组（Х^2=6．838、5．851，均P〈0．05）；两组治疗后心绞痛频率、心绞痛持续时间、每搏输出量（SV）、射血分数（EF）均较治疗前明显改善，治疗后观察组与对照组心绞痛频率、心绞痛持续时间、SV、EF分别为（2．69±0．46）次／min与（6．46±0．62）次／min，（3．26±0．32）min与（5．54±0．42）min，（49．7±3．4）ml与（43．2±2．8）ml，（69．2±5．9）％与（55．3±4．8）％，观察组心绞痛频率、心绞痛持续时间明显低于对照组，SV、EF明显高于对照组，差异均有统计学意义（均P〈0．05）。结论丹参川芎嗪、曲美他嗪、前列地尔联合治疗不稳定型心绞痛临床疗效确切，降低心绞痛发作频率及持续时间，有效改善心肌供血功能，改善心功能，值得临床推广使用。

Objective To evaluate the feasibility of the joint method containing salvia tetramethylpyrazine, trimetazidine, alprostadil in the treatment of unstable angina. Methods 70 unstable angina patients met the inclusion criteria were randomly divided into the observation group of 35 cases and the control group of 35 cases. The control group was given trimetazidine 20mg, tid, and alprostadil 100mg, 1 qd. The observation group were given salvia tetram- ethylpyrazine 10ml on the basis of the control group, qd. Two groups were treated for 14d. The frequency and duration of angina attack was observed. The ECG was monitored. Clinical efficacy differences was compared before and after treatment. Results The total effective rate of the observation group was 100%. The effective rate were 86%. The con- trol group were respectively 91% and 60%. The total effective rate of observation group was significantly higher than the control group（ X^2 = 6. 838,P 〈0.05 ）. The effective rate of observation group was significantly higher than the control group （ X^2 = 5.851, P 〈 0.05 ）. Theanginafrequency, anginaduration, strokeoutpntquantity （ SV ） , ejection fraction（EF） of the observation group and the control group after treatment improved significantly than before treat- meat, after the treatment the angina frequency, angina duration, stroke output quantity（ SV）, ejection fraction （EF） of the observation group and the control group were respectively （2.69 ± 0.46 ）time/rain vs （6.46 ±0.62）time/min, （3.26±0.32）minvs （5.54±0.42）min,（49.7±3.4）ml vs （43.2±2.8）ml,（69.2±5.9）% vs （55.3 ± 4. 8 ） %, the angina frequency, angina duration of the observation group was significantly lower than the control group, and the stroke output quantity （SV）, ejection fraction（EF） of the observation group were significantly higher than the control group （ all P 〈 0.05 ）. Conclusion The joint method containing salvia tetramethylpyrazine, trimetazidine, alprostadil have exact clinical efficacy, reduce the time of angina attack frequency and duration, effectively improve myocardial blood supply, improve heart function, which is worthy of clinical use.