子痫前期患者子宫蜕膜组织中树突状细胞的研究

Study of dendritic cells in decidual tissue of patients with preeclampsia

目的研究子痫前期患者子宫蜕膜组织中树突状细胞的形态、分布及数量,探讨其在子痫前期发病机制中的作用。方法采集各40例正常妊娠孕妇、子痫前期轻度及重度患者子宫蜕膜组织,采用免疫组化法分别检测CD83+、CD1a+树突状细胞的形态、数量及分布。结果 (1)CD83+树突状细胞在子痫前期(重度)组比子痫前期(轻度)组增多,正常组表达最少,各组比较差异均有统计学意义(P<0.01)。(2)CD1a+树突状细胞在正常组表达最高,子痫前期(重度)组比子痫前期(轻度)组降低,各组比较差异均有统计学意义(P<0.01)。结论树突状细胞可能在子痫前期的发病机制中起到一定的作用。

Objective： To study preeclampsia of patients decidual tissues of dendritic cells morphology,distribution,and the number,and explore its role in the pathogenesis of preeclampsia.Method： Respectively collected 15 cases of normal pregnancy,preeclampsia mild and severe patients with uterine decidual tissue.By immunohistochemistry respectively were used to detect CD83＋,CD1a＋ dendritic cell morphology,amount and distribution.Result：（1） CD83＋ dendritic cells in pre-eclampsia（severe） group than in preeclampsia（mild） group were increased the expression,the normal group expression were least,the group differences were statistically significant（P0.01）.（2） CD1a＋ dendritic cells in the normal group expression of the highest,the pre-eclampsia（severe） group than in preeclampsia（mild） were decreased,the group differences were statistically significant（P0.01）.Conclusion： Dendritic cells in preeclampsia of pathogenesis mechanism may play a role.