钦州地区2009年-2011年新生儿CH筛查数据分析

Neonatal screening for congenital hypothyroidism in Qinzhou between 2009 and 2011

目的对钦州市新生儿疾病筛查中心2009年-2011年CH筛查的数据进行总结和分析,以促进新生儿疾病筛查工作。方法用DELFIA法测定干血片TSH值,将TSH值≥10μU/mL判定为初筛阳性,召回确诊。结果共筛查新生儿113 886例,初筛TSH值呈正偏态分布,初筛阳性共553例,召回372例,召回率为67.27%,确诊CH患儿42例,检出率为0.369‰,男女比例为1∶0.68。42名CH患儿初筛CH最低值为10.4μU/mL,最高值为244μU/mL。结论应加强对新生儿疾病筛查工作的力度,提高阳性召回率,以降低出生缺陷,提高我市出生人口素质。

Objective： To summarize neonatal screening for congenital hypothyroidism（CH） in Neonatal Screening Center of Qinzhou between 2009 and 2011,and to guide for future screening work.Methods： CH was screened by thyroid stimulating hormone（TSH） measurement by dissociation-enhanced lanthanide fluorescent immunoassay（DELFIA）.The results were regarded as positive when the TSH value ≥10μU/mL.All of them were recalled for diagnosis test.Results： Between 2009 and 2011,totally of 113 886 neonates were screened for CH in Qinzhou,the values of TSH in preliminary screening was positive skew distribution,553 cases were regards as positive.With a 67.27% recall rate,372 cases were recalled for diagnosis test,and 42 cases of CH were detected.The morbidity rate of CH in Qinzhou was 0.369‰,the ratio of male and female cases was 1∶0.68.During the 42 cases of CH,the values of TSH in preliminary screening were between 10.4μU/mL and 244μU/mL.Conclusion： The neonatal screening management should be strengthen for raising the recall rate with the purpose of reducing the occurrence of birth defects and improving the quality of the newborns in Qinzhou.