HCG日优势卵泡群对IVF-ET周期临床结局的影响

Assess the impact of dominant follicle group on HCG injection day during in vitro fertilization on clinical outcomes

目的探讨人绒毛膜促性腺激素(HCG)注射日优势卵泡群对体外受精-胚胎移植(IVF—ET)周期促排卵周期临床结局的影响。方法回顾性分析2010年7～10月和2011年7～10月在我院生殖医学中心进行长方案/拮抗剂方案促排卵IVF-ET病例资料,共269个周期。根据年份的不同将其分为两组:A组(2011年)∶150个周期;B组(2010年)∶119个周期。分析两组患者年龄、基础性激素、促性腺激素(Gn)用量、hCG注射日的优势卵泡群与IVF-ET临床结局的关系。结果两组患者的一般情况如平均年龄、平均不孕年限、体重指数、基础性激素等比较均无显著统计学差异(P>0.05),但两组Gn天数、hCG日优势卵泡均值、E2峰值、获卵数、可用胚胎数及受精率相比,具有显著性统计学意义,(P<0.05)。结论在IVF—ET周期hCG日优势卵泡群的大小是预测卵子受精的可靠指标,但在预测临床妊娠结局方面的价值还需要大样本量的深入研究。

Objective： To evaluate dominant follicle group on human chorionic gonadotropin（HCG） injection day during ovarian stimulation cycle on clinical outcomes of in vitro fertilization-embryo transfer.Method and materials： A total of 269 fresh cycles during in vitro fertilization-embryo transfer between 2010 and 2011 from July to October at our center were evaluated retrospectively in the study.Cycles were divided into two groups according to the different year： there was 150 cycles in group A,and the remaining 119 cycles in group B.Age,basal sex hormones,gonadotropin dosage,the dominant follicle group on HCG injection day were analyzed to assess the relationships of clinical outcomes between two groups.Results：The general features such as patient′s age,average infertility duration,body mass index,basal sex hormones between two groups were not statistically different（P0.05）.however,to compare the gonadotropin days,the average dominant follicle diameter on HCG day,the peak of estradiol,the number of retrieved oocytes,the number of available embryos and fertilization rate in this two group,there are statistically different（P0.05）.Conclusion： It is a reliable indicator that the dominant follicle group on HCG day in vitro fertilization-embryo transfer to forecast oocyte fertilization,but it need more deep study of large scale sample to explore its value in predicting the clinical outcomes.