期刊文献+

子宫内膜异位症DNA异常甲基化的研究进展

原文传递
导出
摘要 DNA甲基化介导的表观遗传修饰是一种重要的基因表达和调控方式,在胚胎发育、肿瘤的发生及其它疾病中发挥重要作用,近年研究发现DNA甲基化引起的相关基因异常表达对子宫内膜异位症发生发展有着重要影响。本文回顾相关基因异常甲基化与子宫内膜异位症发生、诊断、治疗及预后判断的关系,进一步探讨在子宫内膜异位症发病机制中相关基因异常甲基化的作用,并推断DNA甲基化可以成为EMs有效的诊断标记物。
作者 张丽 邱晓红
出处 《中国优生与遗传杂志》 2013年第2期3-4,45,共3页 Chinese Journal of Birth Health & Heredity
  • 相关文献

参考文献2

二级参考文献18

  • 1赵岩,张淑兰,杨清.散发性子宫内膜癌组织中错配修复基因hMLH1表达与微卫星不稳定性的相关性分析[J].中华肿瘤防治杂志,2007,14(10):772-775. 被引量:9
  • 2Sampsons JA.Endometrial carcinoma of the ovary,arising in endometrial tissue in that organ.Arch Surg,1925,10:1-72.
  • 3Scott RB.Malignant changes in endometriosis.Obstet Gynecol,1953,2:283-289.
  • 4Fukunage M,Nomura K,Ishikawa E,et al.Ovarian atypical endometriosis:its close association with malignant epithelial tumours.Histopathology,1997,30:249-255.
  • 5Matsuzaki S,Canis M,Vaurs-Barriere C,et al.DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection.Fertil Steril,2005,84 Suppl 2:1180-1190.
  • 6Guan H,Ji M,Hou P,et al.Hypermethylation of the DNA mismatch repair gene hMLH1 and its association with lymph node metastasis and T1799A BRAF mutation in patients with papillary thyroid cancer.Cancer,2008,113:247-255.
  • 7Gomori E,Pal J,Meszaros I,et al.Epigenetic inactivation of the hMLH1 gene in progression of gliumas.Diagn Mol Pathol,2007,16:104-107.
  • 8Furlan D,Carnevali I,Marcomini B,et al.The high frequency of de novo promoter methylation in synchronous primary endometrial and ovarian carcinomas.Clin Cancer Res,2006,12 (11 Pt 1):3329-3336.
  • 9Vigano P,Somigliana E,Chiodo I,et al.Vercellini P.Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriasis:a critical analysis.Hum Reprod Update,2006,12:77-89.
  • 10Fernandes AM,Ramos-Jorge ML,Cardoso SV,et al.1mmunoexpression of hMSH2 and hMLHl in oral squamous cell carcinoma and its relationship to histological grades of malignancy[J].Oral Pathol Med,2008,37(9):543-548.

共引文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部