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GnRHa对子宫内膜异位症血管生成素-2的影响 被引量：3

The effects of angiopoietin-2 by GnRHa for endometriosis
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摘要 目的探讨血管生成素-2(angiopoietin-2,Ang-2)在子宫内膜异位症(EMs)发生、发展中的作用以及促性腺激素释放激素类似物(GnRHa)对EMs在位内膜、异位内膜中Ang-2表达的影响。方法选择25例卵巢子宫内膜异位症(OEMs)病人作为未用药组,23例OEMs病人术前使用GnRHa 3个疗程,28例同期非内膜疾病妇女作为对照组。均留取子宫内膜,使用免疫组化染色方法检测Ang-2在OEMs用药及未用药组异位、在位子宫内膜及对照组正常子宫内膜中的表达。结果 Ang-2蛋白主要定位于子宫内膜腺上皮细胞的胞浆中。未用药组:Ang-2在OEMs组在位子宫内膜组织中的阳性表达率为80.00%,显著高于异位内膜(52.00%)和对照组(21.48%)(P<0.05);异位内膜组阳性表达率为52.00%,显著高于对照组(21.48%)(P<0.05)。Ang-2在GnRHa治疗后的表达情况:OEMs者在位内膜中的表达(60.87%)虽然低于未治疗组(80.00%),但差异无统计学意义(P>0.05),但仍明显高于对照组(21.48%)(P<0.05),异位内膜组织中的表达治疗组(30.43%)显著低于未治疗组(52.00%)(P<0.05),在位内膜中的表达仍显著高于异位内膜(P<0.05)。结论 Ang-2在子宫内膜异位症发生发展中起到重要的作用,GnRHa对异位内膜中的Ang-2表达有抑制作用。 Objective： To explore the effect of Angiopoietin-2（Ang-2） in genesis and development of endometriosis,andeffects of angiopoietin-2 by GnRHa for endometriosis.Methods： 25 ovarian endometriosis cases untreated,23 ovarian endometriosis cases by treated with GnRHa for 3 times.28 patients without endometriosis were selected control.All endometrial specimens were collected.Ang-2 was detected by Immunohistochemistry.Results： Ang-2 proteins was expressed in the cytoplasm of glandular epithelium cells.In untreated group：The Ang-2 positive rate was 80.00% in eutopic endometrium in the OEMs,which was significantly higher than that of ectopic endometrium in the OEMs（52.00%） group or the control group（21.48%）（P0.05）;The Ang-2 positive rate was 52.00% in ectopic endometrium in the OEMs group,which was significantly higher than that of control group（21.48%）（P0.05）.After treaterment by GnRHa：Although the Ang-2 expression in eutopic endometrium less than that of ectopic endometrium but No significant differences.The Ang-2 positive rate in eutopic endometrium was significantly higher than that control group（P0.05）.In ectopic endometrium,Ang-2 positive rate in treated group was significantly less than that of untreated group（P0.05）.Conclusion： The effect of angiopoietin-2 in angiogenesis of endometriosis are important.GnRHa may inhibit expression of Ang-2 in ectopic endometrium.
作者 范俊 栾少红 孙宝治 董文韬 夏宝国
机构地区 山东省青岛市市立医院东院妇科 山东省青岛即墨市人民医院妇产科
出处 《中国优生与遗传杂志》 2013年第2期63-64,54,共3页 Chinese Journal of Birth Health & Heredity
关键词 子宫内膜异位症 血管生成素-2 血管生成 促性腺激素释放激素类似物 Endometriosis Angiopoietin-2 Angiogenesis GnRHa
分类号 R711.71 [医药卫生—妇产科学]
  • 相关文献

参考文献11

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二级参考文献9

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共引文献19

同被引文献30

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中国优生与遗传杂志
2013年 第2期

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