老年人原发性高血压与良性前列腺增生的相关性研究

Correlation between primary hypertension and benign prostatic hyperplasia in the elderly

目的探讨老年原发性高血压与良性前列腺增生的关系。方法选取我院2010年8月至2012年6月就诊的老年男性良性BPH患者135例，其中高血压组70例，非高血压组65例，详细患者询问病史，测量身高、体质量，计算体质指数，并进行血脂、血糖、血清前列腺特异性抗原测定，采用国际前列腺症状评分表（IPSS）对其进行评价，通过腹部超声测量前列腺体积。结果高血压组IPSS评分较非高血压组升高，分别为（18．9±7．5）分与（13．2±7．8）分（P〈O．05）；前列腺体积大于非高血压组，分别为（43．0±15．4）ml与（39．2±13．9）ml（P〈0．05）。单变量分析结果显示，年龄、高血压病程与前列腺体积呈正相关（r=0．34，0．29，P％0．05）。校正年龄后，高血压组中高血压病史≥15年组的患者其前列腺体积较高血压病史〈15年组增大（P〈0．05）。结论老年高血压与良性前列腺增生的发生有关，高血压对良性前列腺增生的影响与其病程长短有关，长期高血压促进了良性前列腺增生的发生和临床进展。

Objective To explore the prostatic hyperplasia （BPH） in the elderly. relationship between primary hypertension and benign Methods From August 2010 to June 2012, 135 consecutively referred patients with BPH were enrolled in this study, in which 70 cases were BPH with hypertension, 65 cases were isolated benign prostatic hyperplasia. All patients were questioned in detail about history, body weight and height were measured to calculate the body mass index （BMI）. Prostate specific antigen （PSA） and fasting plasma glucose （FPG） and lipids were assayed in the study. The international prostate symptom score （IPSS） were recorded. Prostate volume （PV） was detected by abdominal ultrasound. Results The levels of IPSS and PV were higher in BPH with hypertension than simple BPH group ^（18.9^7.5）scores vs. （13.2~7.8） scores, P^0.05 ;（43.0~ 15.4） ml vs. （39.2~13.9） ml, P^0.05~. Pearson analysis showed that PV was positively correlated with age and the years of hypertension （r = 0.34,0. 29, P~ 0. 05）. After adjustment for age, PV was significantly greater in hypertension group with more than 15 years compared to less than 15 years of hypertension group. Conclusions Hypertension, particularly long-term hypertension is related to BPH in the elderly. The long term of hypertension may accelerate the occurrence and clinical progression of BPH.