摘要
糖尿病视网膜病变是糖尿病最严重的微血管慢性并发症之一,其发病机制复杂,至今尚未完全阐明。新的研究发现视网膜炎症在糖尿病视网膜病变的发病机制中起重要作用。一些常见的炎症因子在糖尿病视网膜病变的血清、玻璃体、房水中含量增加,它们之间的相互作用影响了疾病的发生发展。本文就炎症在糖尿病视网膜病变中作用的研究新进展作一综述,分析更多的分子机制以寻找可能的治疗靶点。
Diabetic retinopathy is one of the most severe and common chronic complications of diabetes,and it is the leading cause of blindness.The pathogenesis is very complex and has not been elucidated completely.Many new studies indicate that retinal inflammation plays an important role in the pathogenesis of diabetic retinopathy.There are common sets of inflammatory cytokines that are up-regulated in both serum,vitreous and aqueous samples in subjects with diabetic retinopathy,and these cytokines can have multiple interactions to impact the pathogenesis of the disease.This article reviews the related inflammatory cytokines and their functions in diabetic retinopathy,giving insights into the development of potential molecular targets for trea- ting diabetic retinopathy.
出处
《眼科新进展》
CAS
北大核心
2013年第2期197-200,共4页
Recent Advances in Ophthalmology
