人工授精周期诱导排卵药物及方案的研究进展

Program of Ovulation Induction Drugs and Protocols for Intrauterine Insemination (IUI)

诱导排卵联合宫腔内人工授精是广泛应用的一项辅助生育技术。诱导排卵目的是形成单一卵泡的发育成熟,尽可能地减少发生多胎妊娠和卵巢过度刺激综合征的风险。抗雌激素类和芳香化酶抑制剂因口服方便而广泛应用,单独使用妊娠率较低。促性腺激素类药物可以获得较高的临床妊娠率,采用小剂量递增的温和方案不但能够保证较高的单卵泡发育还能够明显的减少并发症的发生。关于促性腺激素促排卵治疗中卵巢反应预测因子还有待于进一步研究。

Intrauterine insemination combined with ovarian stimulation has been demonstrated to be a widely used form of treatment for subfertile couples. The purpose of ovulation induction is the formation of mono- follicular maturation, as much as possible to reduce the risk of occurrence of multiple pregnancies and ovarian hyperstimulation syndrome. Anti-oestrogens and aromatase inhibitors have been widely applied although the pregnancy rate is lower when used alone. Gonadotrophin is better for anovulatory women to get mono-follicular development and higher clinical pregnancy rate, low-dose protocols can reduce the complication rate. Predictors of ovarian response need further studies.