3178周期宫腔内夫精人工授精临床结局及其影响因素分析

Analysis of 3 178 IUI Cycles to Determine Clinical Outcomes and Its Associated Factors

目的:评估宫腔内夫精人工授精(IUI)的临床结局及其影响因素。方法:回顾性分析行IUI治疗的1 646对夫妇共3 178个周期的临床资料,分析临床妊娠率及其与女方年龄、不孕类型、不孕病因、是否促排卵治疗、IUI时机、IUI周期次数的关系。结果:IUI临床妊娠率为12.4%(394/3 178);对临床妊娠率有统计学意义的影响因素是女方年龄、不孕病因、是否促排卵治疗;而不孕类型、IUI时机、IUI周期次数不影响临床妊娠率。结论:女方年龄、不孕病因、是否促排卵治疗均可影响妊娠率,治疗时应综合考虑多种因素的影响。

Objective： To determine clinical outcomes and its associated factors in intrauterine insemination （IUI）. Methods： A retrospective analysis of 3 178 IUI cycles was conducted on all available records of infertile couples. The relationship of pregnancy rate and its associated factors including female age, the etiology of infertility, ovarian stimulation protocol, the time point of IUI and cycle number of IUI was analyzed. Results： The overall clinical pregnancy rate was 12.4% （394/3 178）. The predictive variables which influenced the pregnancy rate were female age, the etiology of infertility, ovarian stimulation protocol. Pregnancy rate was not related to the type of infertility, cycle number of IUI and the time point of IUI. Conclusion： The optimal treatment should be given according to female age, the etiology of infertility and ovarian stimulation protocol.