可注射nano HA/PAG/CS复合材料的制备与表征

Preparation and characterization of injectable composite of nano HA/PAG/CS

通过原位聚合法制备了可注射纳米羟基磷灰石/天门冬氨酸-谷氨酸共聚物/硫酸钙复合材料(HA/PAG/CS),采用FTIR、XRD、SEM对复合材料的组成结构、表面形貌及力学性能进行了表征,研究了复合材料在模拟体液(SBF)中的降解性能。结果显示:复合材料无机相羟基磷灰石、硫酸钙与有机相天门冬氨酸-谷氨酸共聚物之间存在化学相互作用,具有良好的抗压强度;7周后,复合材料在SBF中完全降解,降解方式为表面降解;在降解过程中,浸泡液的pH值在6.4～7.4之间变化;复合材料在SBF中浸泡后,其表面能够沉积磷灰石,表明复合材料具有良好的生物活性,有利于植入体与骨组织形成良好的界面结合。

A new kind of injectable composite of nano hydroxyapatite/aspartic acid- glutamic acid copolymer/ calcium sulfate（nano HA/PAG/CS） was prepared by using polymerization in situ. The composition, structure, surface morphology and mechanical strength of the composite were characterized by FTIR, XRD and SEM etc, and its degradability was investigated in simulated body liquid（SBF）. The results show that the interaction appear between the inorganic and organic phase of the composite. The composite exhibits good compressive strength and degrads totally after soaking in SBF for 7 weeks with surface degradation methods. In the degradation process, the pH of SBF solution changes from 6.4 to 7.4. The composite has good bioactivity because the apatite can be formed on its surfaces after soaking into SBF, which is very useful for the formation of interface combination between implant and tissue.