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乳腺“干细胞（CK5／6^＋）学说”与导管上皮良恶性增生的诊断 被引量：3

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摘要 一、乳腺“干细胞学说”与导管上皮良恶性增生的组织发生传统上认为乳腺上皮由2种细胞组成：腔缘腺上皮细胞及肌上皮细胞。由此认为：乳腺普通型增生与乳腺癌的发生是由乳腺腔缘上皮细胞不同程度的分化所致，是一个连续的组织学谱系，即都源自腔缘上皮，由增生→不典型增生→癌变，最后演化成浸润性乳腺癌。
作者 黄受方
机构地区 北京友谊医院病理科
出处 《中华病理学杂志》 CAS CSCD 北大核心 2013年第2期73-77,共5页 Chinese Journal of Pathology
关键词 肌上皮细胞 不典型增生 乳腺上皮 细胞学说 良恶性 导管 干细胞 浸润性乳腺癌
分类号 R737.9 [医药卫生—肿瘤]
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参考文献12

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同被引文献14

  • 1于志勇,于金明,吴泰璜,卓培英,王圣芳,李美,张霞,吕宝玉,刘雁冰.乳腺癌分子生物学特性检测的临床意义[J].中华肿瘤杂志,2005,27(7):420-422. 被引量：14
  • 2Gostarelli L, Campagna D, Mauri M, et al. Intraductal proliferative lesiom of the breast-terminology and biology matter: premalignant lesions or preinvasive cancer? [ J]. Int J Surg Oncol, 2012, 2012:501904.
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  • 5Boecker W, Buerger H. Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium : a new progenitor ( adult stem) cell concept [ J ]. Cell Prolif, 2003, 36(Suppl) 1:73-84.
  • 6MacGrogan G, Arnould L, de Mascarel I, et al. Impact of immuno- histochemical markers, CK5/6 and E-cadherin on diagnostic agreement in non-invasive proliferative breast lesions [ J 1. Histopathology, 2008, 52(6) :689-697.
  • 7Moriya T, Kasajima A, Ishida K, et al. New tretMs ff ihistcchenstry for making differential diagnosis of breast lesions [ J ]. Med Mol Morphol, 2006, 39(1):8-13.
  • 8Jain RK, Mehta R, Dimitmv R, et al. Atypical ductal hyperplasia: intembserver and intraobserver variability [ J ]. Mod Pathol, 2011, 24(7) :917-923.
  • 9Li L, Wang Q, Lv X, et al. Expression and localization of estrogen receptor in human breast cancer and its clinical significance [ J ]. Cell Biochem Biophys, 2015, 71 ( 1 ) :63-68.
  • 10Shaaban AM, Sloane JP, West CR, et al. Breast cancer risk in usual ductal hyperplasia is defined by estrogen receptor-alpha and Ki-67 expression [ J ]. Am J Patho|, 2002, 160 (2) : 597-604.

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中华病理学杂志
2013年 第2期

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