摘要
With the rapidly rising incidence of diabetes, one of its complications, diabetic nephropathy （DN） is becoming one of the most common causes of end-stage renal disease in many countries. Reliable animal models of DN are a valuable tool for identifying the molecular mechanisms responsible for this disease and preclinical development of new therapeutic strategies. Various types of animal models have been used in the past; the induced methods and characteristics of these commonly used animal models were summarized in this review.
With the rapidly rising incidence of diabetes, one of its complications, diabetic nephropathy （DN） is becoming one of the most common causes of end-stage renal disease in many countries. Reliable animal models of DN are a valuable tool for identifying the molecular mechanisms responsible for this disease and preclinical development of new therapeutic strategies. Various types of animal models have been used in the past; the induced methods and characteristics of these commonly used animal models were summarized in this review.
基金
This work was supported by the Natural Science Foundation of Anhui Province （No. 11040606M159） and the Natural Science Foundation of Anhui Provincial Colleges and Universities （No. KJ2011A157）.
