太原市四社区高血压两类降压药物规范治疗低危患者疗效分析

Study on the effect of two types of antihypertensive drugs used to treat low-risk patients from four communities in Taiyuan

目的为正确评价社区高血压规范化管理中钙拮抗剂和复方制剂治疗高血压低危患者的疗效。方法随访监测太原市四社区接受钙拮抗剂和复方制剂类药物患者各60例,编程在SAS PROC MIXED过程中实现。结果太原市山毛社区血压估计值为80.493 3mm Hg,平阳社区80.503 3mm Hg,双塔中心77.143 3mm Hg,厂矿社区73.620 0mm Hg,4个社区血压值差异有统计学意义(P<0.05)。钙拮抗剂组较复方制剂组血压值高1.22mm Hg,尚不能认为两药物组血压值差异有统计学意义(P=0.152 7)。治疗后患者血压值均随时间有明显下降(P<0.05)。收缩压在治疗3个月下降6.65mm Hg,治疗6个月下降1.816 7mm Hg,治疗9个月下降0.366 7mm Hg。舒张压在治疗3个月下降4.241 7mm Hg,治疗6个月、9个月分别下降1.375 0mm Hg、0.483 3mm Hg。结论钙拮抗剂和复方制剂都是社区规范化管理中低危患者控制血压安全有效的药物。

Objective To evaluate the effect of two types of antihypertensive drugs as calcium channel blockers and compound preparations used for the standardized treatment of low-risk patients in four communities in Taiyuan.Methods A total of 120 low-risk patients with hypertension were enrolled into the study.Half patients were treated with calcium channel blocker drug and another half were treated with compound preparation.The effects of these two drugs were evaluated and analyzed by SAS PROC MIXED.Results The estimated blood pressures of patients in Shanmao,Pingyang,Shuangta and Changkuang community were 80.493 3,80.503 3,77.143 3 and 73.620 mm Hg.There were significant differences of blood pressure among patients in four communities（P0.05）.Although the blood pressure of patients treated with calcium channel blockers was 1.22 mm Hg higher than those treated with compound preparation,no statistical difference was found（P=0.152 7）.The BP of all patients decreased over the time after treatment（P0.05）with the systolic and diastolic BP decreased by 6.65 and 4.241 7 mm Hg,1.816 7 and 1.375 0 mm Hg,0.366 7 and 0.483 3 mm Hg three months,six and nine months after treatment.Conclusions Calcium channel blockers and compound preparations are both effective antihypertensive drugs which can be used for the standardized treatment of low-risk patients in communities.