肝病患者甲状腺功能状况分析及意义

Analysis of the Thyroid Function of Patients with Different Types of Liver Diseases

目的探讨肝病患者的血清甲状腺素水平与肝病的关系。方法采用放射免疫法对145例肝病患者血清中的T3、T4、FT3、FT4、TSH进行检测分析。结果急性肝炎和慢性活动性肝炎治疗前T4较对照组明显升高，有显著性差异。代偿期肝硬化、失代偿期肝硬化治疗前T3、T4较对照组有不同程度降低，结果有显著性差异，且失代偿期肝硬化治疗前T3、T4降低程度较代偿期肝硬化大。结论肝病患者常伴有甲状腺功能异常，在慢性活动性肝炎及急性肝炎时常常会出现T4增高或高T4综合征，在肝硬化时常常会出现T3、T4降低或低T3、低T4综合征。

Objective To investigate the association of thyroid function with different types of liver diseases. Methods A cross-sectional study was performed among 145 patients with liver diseases.Serum T3,T4,FT3,FT4,TSH levels were analyzed by radioimmunoassay.Result Patients with acute hepatitis or chronic active hepatitis had significantly higher levels of serum T4 before treatment than those of controls.Patients with compensated cirrhosis or decompensated cirrhosis had significantly lower levels of serum T3,T4 before treatment than those of controls,and moreover, the level of serum T3,T4 in patients with decompensated cirrhosis reduced more than in patients with compensated cirrhosis.Conclusion Thyroid dysfunction commonly occurs in patients with liver diseases.Higher levels of serum T4 or high T4 syndrome were observed in chronic active hepatitis and acute hepatitis,while lover levels of serum T3,T4,or low T3/T4 syndrome were observed in liver cirrhosis in our study.