血清IGF-1及CEA、CYFRA21-1检测联合18F-FDGPET／CT在肺癌诊断和复发监测中的价值研究

The Comparative Study of Diagnostic Value of Serum IGF-1,CEA and CYFRA21-1 Combined with 18F-FDG PET/CT on Lung Cancer

目的评价和比较血清IGF-1及CEA、CYFRA21。1联合检测、氟．18-氟代脱氧葡萄糖18F-FDG）PET／CT及IGF．1联合18F．FDGPET／CT~种方法早期诊断肺癌的临床价值。方法对确诊的18例肺癌患者和1例肺良性病变患者行PET-CT扫描并行血清学IGF．1、CEA和CYFRA21．检测，比较IGF．1＋CEA＋CYFRA21．1、PET／CT、IGF。1＋PET／CT三种方法对肺癌的检出率。结果IGF-1＋cEA＋cYFRA2l-1组合对肺癌诊断的灵敏度、准确率和假阴性率分别为83．3％（15／18）、78．9％（15／19）和16．7％（3／18）；18F—FDGPET／CT显像分别为88．9％（16／18）、89．5％（17／19）和11．1％（2／18）；IGF．1＋18F．FDGPET／CT组合分别为88．9％（16／18）、89．5％（17／19）和11．1％（2／18）。结论IGF-1＋CEA＋CYFRA21．1可作为一种很好的筛查肺癌方法；PET／CT显像对肺癌的诊断有较高的价值；IGF-1与PET／CT联合不能提高诊断肺癌的效能。

Objective To evaluate the diagnostic value of IGF-1 combined with serum tumor markers CEA and CYFRA21-l,positron emission tomography/computed tomography with fluorine-18-labeled fluoredeoxyglucose（lSF-FDG PET/CT）,and IGF-1 combined with 18F-FDG PET/CT on lung cancer.Method 18F-FDG PET/CT scan was performed in 18 lung cancer patients diagnosed and 1 patients with benign pulmonary disease.The serum levels of IGF-1,CEA and CYFRA21-1 were detected in the same persons.The sensitivity, accuracy and false positive rate of the combination of IGF- 1,CEA with CYFRA21-1,PET/CT and the combination of IGF-1 with PET/CT were analyzed.Results The sensitivity, accuracy and false positive rate of the combination of IGF-1 with serum tumor markers CEA and CYFRA21-1 was 83.3%（15/18）,78.9%（15/19） and 16.7%（3/18）,respectively;and those of PET-CT scan was 88.9%（16/18）,89.5%（17/19） and 11.1%（2/18）,respectively;those of the combination of IGF- 1 with PET/CT scan was 88.9%（16/18）,89.5 %（17/19） and 11.1%（2~18）,respectively.Conclusion The combination of IGF-1 with serum tumor markers CEA and CYFRA21-1 was an effective screening method on lung cancer.PET/CT was of great value for the diagnosis of lung cancer;Combination of IGF-1 with PET/CT scan cannot enhance significantly diagnostic efficiency on lung cancer.