氨基末端脑钠肽前体在急诊呼吸困难患者中的应用

The Application of N-terminal Prohormone Brain Natriuretic Peptide in Patients with Acute Dyspnea

目的:探讨氨基末端脑钠肽前体(NT-proBNP)对急诊呼吸困难患者病因鉴别诊断的临床价值。方法:将我科2009年1月至20011年12月以呼吸困难为主要症状的患者364例分为心源性呼吸困难组(A组,n=178例)和非心源性呼吸困难组(n=186例),比较两组患者血浆NT-proBNP浓度。结果:心源性呼吸困难组NT-proBNP浓度(2994.6±518.2)pg/ml明显高于非心源性呼吸困难组(224.5±67.8)pg/ml,P<0.01;且NT-proBNP在不同心功能NYHA分级组间呈显著性差异,P<0.05。结论:床边快速测定血浆NT-proBNP浓度对急诊呼吸困难患者的病因鉴别诊断有较高的应用价值。

Objective： To explore the clinical value of cause different diagnosis of N-terminal prohormone brain natriuretic peptide （NT-proBNP） in patients with acute dyspnea. Methods： The 364 cases of patients with acute dyspnea as mainly symptom were divided into cardiac dyspnea group （n=178） and noncardiac dyspnea group （ n=186 ） from Jan 2009 to Dec 2011.The concentration of NT-proBNP was compared between the two groups. Results： The blood plasma concentration of NT-proBNP in cardiac dyspnea group was significantly higher than that in noncardiac dyspnea group, （2994.6±518.2 ＆ 224.5±67.8） pg/ml, There were significantly different of NT-proBNP among the different classic heart function of NYHA in cardiac dyspnea group,P 〈 0.05. Conclusion： There is high application value of rapid monitoring the blood plasma concentration of NT-proBNP in cause different diagnosis for patient with acute dyspnea.