氟比洛芬酯联合诺仕帕治疗肾绞痛48例临床分析

Clinical Analysis of 48 Patients with Renal Colic Treated by Flurbiprofen Axetil and Drotaverine

目的:观察氟比洛芬酯联合诺仕帕治疗肾绞痛的临床疗效和不良反应。方法:将96例肾绞痛患者随机分成观察组和对照组各48例,两组均静脉注射诺仕帕40 mg,观察组和对照组分别静脉注射氟比洛芬酯50 mg和肌注度冷丁100 mg,比较两组用药后30 min、60 min的疗效和6 h复发情况。结果:两组30 min、60 min的总有效率无统计学差异(P>0.05),观察组不良反应率和再发率均明显低于对照组(P<0.05)。结论:氟比洛芬酯联合诺仕帕治疗肾绞痛疗效确切,不良反应率及肾绞痛再发率低,值得临床推广应用。

Objective： To explore the clinical effect and adverse reaction of Flurbiprofen Axetil and Drotaverine in treatment of renal colic. Methods： 96 patients with renal colic were divided into observation group and control group randomly,and each group contained 48 cases.Patients in observation group were intravenous injected Flurbiprofen Axetil 50 mg while intramuscular injection of pethidine 100 mg were used in control group. Both groups were adopted intravenous injection of Drotaverine 40 mg in addition. The therapeutic effects were compared between the two groups at 30 min and 60 min after treatment, and recurrence rate at 6 h after pain was released. Results： The effective rates were no significant differences between the two groups （P 〉 0.05）. Adverse reaction rate and recurrence rate in observation group were significantly lower than those in the control groups （P 〈 0.05）. Conclusion： Flurbiprofen Axetil combined with Drotaverine has a stable effectiveness for treatment of renal colic, with low risk of adverse reaction and recurrence. This strategy might be considered for clinical application.