蝙蝠蛾被毛孢虫草菌丝体粉对小鼠免疫调节作用的研究

Study on immunune regulation of mycelium of Hirsutella hepiali Chen et Shen in mice

目的探讨蝙蝠蛾被毛孢虫草菌丝体粉对小鼠的免疫调节作用。方法分别以200、400、800mg/kg BW剂量的蝙蝠蛾被毛孢虫草菌丝体粉经口给予小鼠连续灌胃30d后,进行各项免疫指标的测定。结果蝙蝠蛾被毛孢虫草菌丝体粉剂量组与对照组比较能促进小鼠脾淋巴细胞增值、转化作用(P<0.05),促进小鼠的迟发型变态反应(P<0.05),增强小鼠的单核-腹腔巨噬细胞吞噬能力(P<0.05),促进小鼠的抗体生成细胞增加及提高小鼠的血清溶血素水平(P<0.01和P<0.05),提高小鼠的NK细胞活性(P<0.01和P<0.05)。结论蝙蝠蛾被毛孢虫草菌丝体粉具有增强免疫力的功能。

Objective To explore the effect of Mycelium of Hirsutella hepiali Chen et Shen on the function of immunoregulation. Methods The mice were fed with myeelium of Hirsute]la hepiali Chen et Shen at the doses of 200.400 and 800mg/kg.Bw for 30 days and then 7 indexes of immune function were measured to judge the effect of mycelium of Hirsutella hepiMi Chen et Shen on immune system. Results The results of the test groups in comparison with the control group showed that transformation and proliferation of splenic lymphocyte were enhanced （P〈0.05） and the late hairstyle allergy in mice was gearedup （P〈0.05） ; The mononuclear celiac macrophage phagocytic activity was increased （P〈0.05） ;the quantity of the mice antibody-producing cell and the sheep erythrocyte antibody levels in serum were boosted （P〈0.01 and P〈0.05） and enhanced the activity of NK ceils in mice （P〈0.05）. Conclusion It is suggested that mycelium of Hirsutella hepiMi Chen et Shen could enhance immune function.