血清KLOTHO浓度与冠状动脉粥样硬化性心脏病的关系

Relation of serum KLOTHO level and coronary artery disease

目的探讨抗衰老因子KLOTHO与冠状动脉粥样硬化性心脏病(冠心病)发病的关系。方法对80例冠心病患者与100例对照者进行危险因素调查,采用酶联免疫吸附试验(ELISA)法测定静脉血KLOTHO表达浓度。结果冠心病组吸烟、原发性高血压(高血压)、高脂血症、糖尿病均显著高于对照组(P<0.05);冠心病组血清KLOTHO浓度低于对照组,差异有统计学意义[30(16.10～89.00)pg/mL vs.38(21.60～231.00)pg/mL,Z=-4.998,P<0.001]。以KLOTHO血清值的中位数35 pg/mL作为分界值,高血清KLOTHO的OR值为0.420,95%可信区间0.206～0.858。结论血清KLOTHO表达水平与冠心病相关,可能对于预防冠心病有保护效应。

Objectives To explore the relationship between anti-aging factor KLOTHO and coronary artery disease （CAD）. Methods Risk factors of coronary artery disease were investigated in 80 patients with CAD and 100 controls. The expression level of serum KLOTHO was determined by enzyme linked immunosorbent assay （ELISA） in both groups. Results The frequencies of smoking, hypertension, hyperlipidemia, diabetes mellitus were significantly higher in CAD group than those in the controls （P〈0.05）. The level of serum KLOTHO in CAD group was significantly lower than that in the controls [ 30 （16.10-89.00） pg/mL vs. 38 （21.60-231.00） pg/mL, Z=-4.998, P〈0.001 ]. Taking the median of serum KLOTHO 35 pg/mL as the eut point, the OR of high serum KLOTHOs was 0.420 （95% CI： 0.206- 0.858）. Conclusions Expression level of serum KLOTHO is associated with coronary artery disease, which indicates that KLOTHO may have a protective effect on CAD.