经鼻持续气道正压通气联合大剂量氨溴索预防早产儿呼吸窘迫综合征

Preventing Premature Infants with Respiratory Distress Syndrome with Nasal Continuous Positive Airway Pressure Combined with Large Dose of Ambroxol Hydrochloride

目的探讨经鼻持续气道正压通气联合大剂量氨溴索预防早产儿呼吸窘迫综合征的疗效。方法选择90例符合标准的早产儿,随机分成观察组A30例、观察组B30例及对照组30例。3组在相同治疗的基础上,观察组A加用经鼻持续气道正压通气联合大剂量氨溴索30 mg(/kg.d),分3次用5%葡萄糖稀释后静脉滴注;观察组B加用大剂量氨溴索(剂量同前)静脉滴注;对照组采用常规治疗。比较3组患儿治疗前后临床表现、胸、血气、血氧饱和度指数的变化,并发症及住院时间。结果观察组新生儿呼吸窘迫综合征发生率明显低于对照组,治疗后观察组A的临床症状体征、胸片、血气指标变化均较观察组B明显改善,合并症少,住院时间缩短。结论经鼻持续气道正压通气联合大剂量氨溴索能有效的预防和降低新生儿呼吸窘迫综合征的发生率。

Objective To investigate the effect of nasal continuous positive airway pressure （NCPAP） combined with large dose of ambroxol hydrochloride to prevent premature infants with respiratory distress syndrome （NRDS） effect. Methods 90 cases of infants were randomly divided into the observation group, A：30 cases; B：30 cases in observation group; the control group： 30 cases. On the basis of comprehensive treatment, the observation group A with nasal continuous positive airway pressure （NCPAP） combined with large dose of ambroxol hydroehloride （trade name： Mucosolvan ） 30 mg （ kg. d ）, 3 with 5% glucose dilution after intravenous in- fusion. The observed group combined with large dose of ambroxol hydrochloride （dose before） intravenous infusion. To observe 3 groups of patients before treatment, clinical manifestations, chest radiography after, blood gas, blood oxygenation index changes, comorbidity, hospitalization time. Results In the observation group, neonatal respiratory distress syndrome was significantly lower than that in the control group, after treatment were observed in group A clinical symptoms and signs, chest X-ray, blood gas indexes were observed in group B were significantly improved, less complications, shorter hospitalization. Conclusion NCPAP combined with large dose of ambroxol hydrochloride can effectively prevent and reduce the neonatal respiratory distress syndrome incidence.