DNA启动子甲基化在涎腺肿瘤转化研究中的作用

DNA promoter methylation and the translational regulation in salivary gland tumors

涎腺肿瘤是口腔颌面部常见的一类肿瘤,该类肿瘤结构复杂,组织学形态与生物学行为变异较大,目前治疗仍以手术为主。但除良性肿瘤及部分低度恶性肿瘤手术治疗效果较好外,大多数涎腺恶性肿瘤因缺乏特异性治疗手段,术后常出现复发、转移。近年来,表观遗传学逐渐成为肿瘤研究的热点,DNA甲基化作为表观遗传学的重要组成部分,对其认识和研究也在不断深入。本文旨在探讨DNA启动子甲基化在涎腺肿瘤的发生、治疗和预后预测中的作用。

Salivary gland tumor is one of the most common tumors in head and neck region with a great variety of morphology and biological behavior. Surgical operation is the major choice of salivary gland tumors. However, except the benign and low-grade malignant tumors, most salivary malignancies are in lack of specific treatment and the recurrent and metastic frequency is pretty high. Epigenetic study has become a hot spot of cancer research in recent years and one of widely studied field is the DNA promoter methylation. Our current article intends to discuss the possible application of DNA promoter methylation in the development, treatment and prognosis of salivary gland tumors.