2009-2011年妇女胃肠炎患者幽门螺杆菌感染现状调查与耐药分析

Current status of Helicobacter pyloriinfections in women with gastroenteritis and analysis of drug resistance during 2009-2011

目的调查镇江地区胃肠炎妇女患者Hp的感染现状,为幽门螺杆菌感染耐药性及合理应用抗菌药物提供依据。方法对妇女患者的幽门螺杆菌(Hp)感染检测结果进行回顾性分析,采用13 C尿素呼气试验检测妇女幽门螺杆菌携带情况。结果共检测2009-2011年住院和门诊就诊妇女病例428例,Hp阳性252例,阳性率58.8%,其中40～59岁组阳性率为63.5%,明显高于18～29岁组(阳性率为47.4%),差异有统计学意义(χ2=5.34,P<0.05),显著低于男性40～59岁组(χ2=35.81,P<0.01);30～39岁组58.6%和>60岁组58.1%,比40～59岁组分别有所下降(χ2=0.37,P>0.05)、(χ2=0.47,P>0.05),镇江妇女幽门螺杆菌感染危险因素可能与重盐饮食、从事服务行业、卫生习惯差、免疫力低下有关;总耐药率为21.4%。结论镇江地区40～59岁妇女Hp感染率明显高于18～30岁,其预防与及早治疗更应重视,幽门螺杆菌引起的地区感染非常严峻,应加强对幽门螺杆菌引起的地区感染耐药性监测,合理应用抗菌药物。

OBJECTIVE To investigate the current status of the Hp infections in the women with gastroenteritis in Zhenjiang so as to provide basis for the monitoring of drug resistance of Hp and the reasonasle use of antibiotics.METHODS The testing results of Helicobacter pylori（Hp） infections were retrospecti cely analyzed,The carrier of Hp in the women was determined by 13C-UBT.RESULTS A total of 428 female outpatients and inpatients were surveyed during 2009-2011.There were 256 cases of positive Hp with the positive rate of 59.8%,among which the positive rate of Hp of the positive women aged from 40 to 59 years old was 63.5%,significantly higher than 47.4% of the patients aged from 18 to 29 years old,the difference was statistically significant（χ2=5.34,P0.05）,meanwhile,significantly lower than that of the male patients aged from 40 to 59 years old,the difference was statistically significant（χ2=35.81,P0.01）.As compared with the patients aged between 40 and 59 years old,the positive rates of the patients aged from 30 and 39 years old（58.6%） and the patients aged more than 60 years old（58.1%） dropped slightly in varying degrees（χ2=0.37,P0.05）,（χ2=0.47,P0.05）.The salt intake,engaging in the service industry,low immunity,and poor hygienic practice were the possible risk factors of the Hp infections in the women of Zhenjiang.The total drug resistance rate of the Hp strains was 21.4%.CONCLUSION The incision rate of the Hp infections is significantly higher in the women aged between 40 and 59 years old than in the women aged between 18 and 30 years old in Zhejiang.The regional infections caused by the Hp strains have been so severe that it is necessary to attach great importance to the prevention and treatment in the early stage,to strengthen the monitoring of the drug resistance,and to reasonably use antibiotics.