女性糖尿病患者泌尿系统感染的细菌分布及耐药性分析

Distribution and drug resistance of pathogenic bacteria causing urinary system infections in female patients with diabetes mellitus

目的对女性糖尿病患者合并泌尿系统感染的相关情况进行分析,以了解病原菌的分布及耐药性。方法对183例女性糖尿病患者合并泌尿系统感染的尿细菌分布及耐药性进行分析。结果分离出的117株病原菌以革兰阴性菌为主,占检出的82.1%,其中两种主要致病菌大肠埃希菌和肺炎克雷伯菌,对于半合成的广谱青霉素类抗菌药物氨苄西林耐药率最高,分别为71.2%和72.7%;而对亚胺培南和美罗培南两类碳青霉烯类抗菌药物耐药率为0;革兰阳性菌中的主要致病菌金黄色葡萄球菌,对于青霉素的耐药率为100.0%,而在新糖肽抗菌药物替考拉宁、万古霉素和呋喃妥因中耐药率为0。结论临床应注意抑制抗菌药物的滥用,并根据患者的实际合理用药,以获得较好的治疗效果。

OBJECTIVE To analyze the distribution and drug resistance of pathogenic bacteria causing urinary system infections in the female patients with diabetes mellitus.METHODS Totally 183 female patients combined with diabetes mellitus and urinary system infections were chosen and studied to analyze the distribution and drug resistance of the pathogenic bacteria.RESULTS A total of 117 strains of pathogens were isolated,and the gram-negative bacteria remained the predominant pathogens,accounting for 82.1%.The drug resistance rates of the Escherichia coli and Klebsiella pneumoniae which were the main species of pathogens to the semi-synthetic broad spectrum penicillins were 71.2% and 72.7%,the drug resistance rates to such two types of carbapenems as imipenem and meropenem were 0.The Staphylococcus aureus was the predominant species of gram-positive bacteria,of which the drug resistance rate to penicillin was 100.0%,and the drug resistance rates to such new glycopeptide antimicrobial agents as teicoplanin,vancomycin,and nitrofurantoin were 0.CONCLUSION It is urgent for the hospital to pay attention to the abuse of antibiotics inhibitors and to prescribe reasonably based on the actual situation of the patients so as to achieve better treatment effect.