乙醇性肝炎合并病毒感染患者的病原学检测分析

Analysis of etiology of viral hepatitis among patients with alcoholic hepatitis

目的探讨乙醇性肝炎合并病毒感染的病原学分布特征,为肝炎的预防治疗工作提供指导依据。方法回顾性分析1472例乙醇性肝炎的临床资料,采用酶联免疫吸附法进行病原学检查。结果 1472例乙醇性肝炎患者中188例感染各类型病毒,感染率为12.77%;男性126例,占67.02%,女性62例,占32.98%;单一感染149例,占79.26%,混合感染22例,占11.70%,未分型17例,占9.04%;单一感染中以乙型肝炎病毒(HBV)和甲型肝炎病毒(HAV)为主,分别占52.13%和14.36%;混合感染包括双重感染17例,三重感染4例,四重感染1例,分别占77.27%、18.18%和4.55%;混合感染中以HAV+HBV和HBV+丁型肝炎病毒(HDV)最常见,分别占22.73%和18.18%。结论乙醇性肝炎合并病毒感染的比例较高,其病原学仍然以HBV为主,但混合感染严重,临床应重点筛查乙型肝炎,并加强对未定型肝炎的检测。

OBJECTIVE To explore the etiology of viral hepatitis among the patients with alcoholic hepatitis so as to provide evidence for the prevention and treatment of hepatitis.METHODS The clinical data of 1472 cases with alcoholic hepatitis were reviewed.The etiology examination was tested by enzyme-linked immunoassay.RESULTS Totally 188 out of 1472 cases were infected by various types of viruses,accounting for 12.77%.126 male cases and 62 female cases were infected,accounting for 67.02% and 32.98%,respectively.Totally 149 cases with single infection and 22 cases with mixed infections were found,accounting for 79.26% and 11.70%,respectively,and 17（9.04%） cases were infected by no（A^E） hepatitis viruses.The hepatitis A virus or hepatitis B virus were the most common among the patients with single infections,accounting for 52.13% and 14.36%,respectively.Among the cases with mixed infections,17 cases with dual infections,4 cases with triple infections,and 1 case with quadruple infections were found,accounting for 77.27%,18.18% and 4.55%,respectively.The hepatitis A virus mixed with hepatitis B virus and hepatitis B virus mixed with hepatitis D virus were the most common in the patients with the mixed infections,accounting for 22.73% and 18.18%,respectively.CONCLUSION The incidence of viral hepatitis is high in the patients with alcoholic hepatitis,and the hepatitis B virus is shown to be the predominant pathogen contributing to the viral hepatitis.But the mixed infections are serious.We should focus on screening the hepatitis B virus,and strengthen the detection of undifferentiated hepatitis.