摘要
目的:观察复方萨都那保对大鼠心肌缺血/再灌注的保护作用。方法:60只SD大鼠随机分为假手术组(只穿线不结扎)、模型组、阳性组(复方丹参片,1.08 g.kg-1)、复方萨都那保低、中、高剂量组(2.9,5.8,11.6 g.kg-1)。连续ig给药7 d,结扎/松绑SD大鼠冠状动脉左前降支,制成急性缺血/再灌注模型,记录各组大鼠Ⅱ导联心电图,监测心律失常的情况,及对心肌梗死面积的影响。结果:与假手术组比较,模型组心律失常发生率、心肌梗死面积、心电图ST-T波和J点的升高程度均显著升高(P<0.01);与模型组比较,阳性组和复方萨都那保低、中、高剂量组再灌注时心律失常发生率,心肌梗死范围,心电图ST-T波和J点的升高程度均降低(P<0.01,P<0.05),且复方萨都那保组呈现剂量依赖性。结论:复方萨都那保对心肌缺血再灌注损伤具有一定的保护作用,可能与其降低心律失常发生率、减小心梗面积,降低心电图ST-T波和J点的升高程度有关。
Objective： To investigate the protective effects of compound Nepeta angustifolia on myocardial ischemia/reperfusion-induced injury （I/R） in rats. Method： Sixty SD rats were divided into 6 groups randomly： sham group （onlyneddle not ligation） , model group, positive group （compound danshen tablets, 1.08 g .kg-1） , N. angustifolia groups low-does, medium-does and high-does group （2.9, 5.8, 11.6 g kg-Z）. Rats were continuous gavaged for 7 days, the ligation/relaxat-ion of left anterior descending artery was used to establish acute ischemia/reperfusion model, meanwhile monitoring II ECG, arrhythmia and infarcted zone. Result： Compared with control, I/R group increased the incidence of reperfusion arrhythmia, infarcted zone and growth of J point and ST-T wave （P 〈 0.01）. Compared with I/R group, N. angustifolia groups reduced the incidence of reperfusion arrhythmia; delaying arrhythmia time; shorten the arrhythmia duration; diminished infarcted zone; reduced the growth of J point and ST-T wave on ECG, also slowed the heart rate of rats （P 〈 0.01, P 〈 0. 05）. Conclusion ： N. angustifolia can play a protective role in myocardial ischemia/reperfusion-induced injury, which maybe relate to that N. angustifolia can reduce the incidence of arrhythmia; diminish infarcted zone; reduce the growth of ST- T wave and J point.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第4期262-265,共4页
Chinese Journal of Experimental Traditional Medical Formulae
