方和谦教授验方降脂汤治疗高血脂症

Clinical Research on Jiangzhi Decoction in Treatment of Hyperlipidemia by Professor Fang He-qian

目的:探讨国医大师方和谦教授验方降脂汤治疗高脂血症的临床疗效。方法:180例高脂血症患者随机分为治疗组、血脂康组和辛伐他汀组各60例。治疗组采用降脂汤方(配方颗粒),1剂/d,口服;血脂康组,2粒/次,2次/d,口服;辛伐他汀组,20 mg,1次/d,口服。疗程8周。观察血脂水平及痰浊阻遏证。结果:治疗组总有效率为79.31%,血脂康组为71.92%,辛伐他汀组为84.75%,3组差异不明显;治疗组证候疗效总有效率94.82%,优于血脂康的78.94%和辛伐他汀组的67.79%(P<0.05,P<0.01);治疗组甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C),载脂蛋白A,B(ApoA,ApoB)、及ApoA/ApoB与辛伐他汀组差异不明显,治疗组TC高于辛伐他汀组(P<0.05);治疗组TC,HDL-C,LDL-C,ApoA及ApoA/ApoB的改善优于血脂康组(P<0.05)。结论:降脂汤具较好的调节脂代谢作用,临床疗效确切,值得进一步研究。

Objective： To investigate the clinical efficacy of Professor Fang Heqian＇s prescription, Jiangzhi decoction （JZD） in treatment of hyperlipidemia. Method： One hundred and eighty patients with hyperlipidemia were randomly divided into treatment group, Xuezhikang group and simvastatin group （n -- 60 each）. The treatment group was treated with JZD （granules） , once daily; patients in Xuezhikang group was given 2 grains bid orally; the patients in simvastatin group was given 20 mg orally per day. The treatment was lasted for 8 weeks. Lipid levels and phlegm-turbidity accumulation syndrome in Chinese medicine were investigated. Result： The total efficiency of the treatment group was 79.31% , Xuezhikang group was 71.92% , and 84.75% in the simvastatin group. No significant difference among the groups was found. The syndromes efficiency of the treatment group was 94.82% , better than 78.94% of Xuezhikang and 67.79% of simvastatin （P 〈 0.05, P 〈 0.01 ）. Triglyceride （TG）, high density lipoprotein-cholesterol （ HDL-C）, low density lipoprotein-eholesterol （LDL-C） , apolipoprotein A （ApoA）, apolipoprotein B （ApoB）, and ApoA/ApoB of the treatment group showed no significant difference compared with those in simvastatin group. The TC of the treatment was higher than the simvastatin group （P 〈 0.05） ; the improvement of TC, HDL-C, LDL-C, ApoA of ApoA/ApoB of the treatment group was better than Xuezhikang group （P 〈 0.05 ）. Conclusion： JZD is promising in regulation of lipid metabolism with good clinical efficacy, and worthy for further study.