冠心宁注射液联合血栓通注射液治疗不稳定型心绞痛

Joint Treatment of Guanxinning Injection with Xueshuantong Injection for Treatment of Unstable Angina of 40 Cases

目的:观察冠心宁注射液联合血栓通注射液治疗不稳定型心绞痛的临床效果。方法:选取80例不稳定型心绞痛患者按入院顺序随机分为两组,对照组40例患者在常规治疗基础上采用葛根素注射液400～600 mg+5%葡萄糖,250 mL,gtt,观察组40例患者在常规治疗基础上采用冠心宁注射液20 mL联合血栓通注射液20 mg,均加入5%葡萄糖注射液gtt,250mL,均治疗2周,治疗前、后检测C反应蛋白CRP,血液流变化各项指标,并进行心电图检查,观察比较两组患者治疗效果。结果:观察组治疗后血液流变学各项指标(红细胞压积、全血黏度、纤维蛋白原)及CRP均较对照组下降更为明显,差异均有统计学意义(P<0.05)。观察组患者治疗后心绞痛症状改善总有效率为87.50%,对照组为65.00%,差异具有统计学意义(P<0.05)。观察组患者心电图检查显效率为75.00%,对照组为50.00%,差异具有统计学意义(P<0.05)。结论:采用冠心宁注射液联合血栓通注射液治疗不稳定型心绞痛,可明显改善患者血流变学各项指标,降低CRP,疗效确切。

Objective： To investigate the joint effect of Guanxinning injection combined with Xueshuantong injection for treatment of unstable angina. Method： Eighty patients with unstable angina patients were randomly divided into two groups by order of admission. Forty patients was treated by conventional therapy based on puerarin injection 400-600 mg＋ 5% glucose 250 mL gtt as the control group, and another 40 patients were treated by joint Guanxinning injection 20 mL 5% glucose 250 mL combined with Xueshuantong injection 120 mg ＋ 5% glucase 250 mL gtt on the basis of the conventional treatment as the observation group. The clinical course was lasted for two weeks. Before and after treatment, C-reactive protein （CRP）, hemorheological parameters, ECG and the outcome of treatment were observed and compared. Result： After treatment, compared with the control group, hemorheological parameters （hematocrit, whole blood viscosity, fibrinogen） and CRP were decreased more significantly （P 〈 0.05）. Angina symptoms were improved in the observation group and the total effective rate was 87.50% , while 65.00% in the control group. The difference was statistically significant （P 〈 0.05）. The ECG effective rate in the observation group was 75.00% , and 50.00% in the control group, with significant difference （P 〈 0.05 ）. Conclusion： The joint effect of Guanxinning injection combined with Xueshuantong injection for treatment of unstable angina can significantly improve hemorheological parameters and reduce CRP.