甲钴胺穴位注射合补气活血通痹汤治疗糖尿病周围神经病变

Clinical Study on Mecobalamine Iadacum Combined with Buqi Huoxie Tongbi Soup for Diabetic Peripheral Nuropathy

目的:观察甲钴胺足三里穴位注射联合补气活血通痹汤治疗糖尿病周围神经病变(DPN)患者的疗效。方法:78例患者随机分为两组,两组均在血糖控制稳定后开始观察;治疗组(40例)给予补气活血通痹汤加甲钴胺足三里穴位注射,对照组(38例)予以补气活血通痹汤加甲钴胺臀部肌肉注射;观察两组治疗前后症状、运动神经传导速度(MNCV)及感觉神经传导速度(SNCV)等指标的变化,疗程均为2周。结果:治疗组总有效率为97.5%,对照组总有效率为84.21%(P<0.05);治疗组治疗后MNCV和SNCV显著改善(P<0.05),且优于对照组(P<0.05或P<0.01);治疗后治疗组症状积分明显低于对照组(P<0.01)。结论:甲钴胺足三里穴位注射联合补气活血通痹汤治疗糖尿病周围神经病变,能显著提高患者MNCV和SNCV,有效改善临床症状,提高生活质量。

Objective： To study the therapeutic effect of mecobalamine Iadacum of Zusanli combined with Buqi Huoxie Tongbi soup （BTS） on patients with diabetic peripheral neuropathy （DPN）. Method： Seventy-eight cases of DPN were divided randomly into two groups. Treatment group with 40 cases was orally given BTS plus mecobalamine Iadacum of Zusanli and control group with 38 cases was orally given BTS plus mecobalamine gluteal region intramscular injection; the clinical symptom, motor nerve conduction velocity （MNCV） and sensory nerve conduction velocity （SNCV） and other indicators were observed; the course of treatment was 2 weeks. Result： The total effective rate was 97.5% in treatment group and 84.21% in control group （P 〈 0.05 ） , respectively; MNCV and SNCV improved better in treatment group than in control group （P 〈 0.01 or P 〈 0.05） ; the integral of clinical symptom was less in treatment group than in control group （ P 〈 0.01 ） after two-week treatment. Conclusion ： Mecobalamine Iadacum of Zusanli combined with BTS in patients with DPN is effective in relieving the clinical symptoms and improving MNCV and SNCV.